Sirpb1

Signal-regulatory protein beta 1

PDB rendering based on 2d9c.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2D9C, 2JJU

Identifiers

Symbols

SIRPB1; CD172b; SIRP-BETA-1

External IDs

OMIM: 603889 HomoloGene: 82993 GeneCards: SIRPB1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• plasma membrane • integral to plasma membrane • membrane • integral to membrane
Biological process	• signal transduction • cell surface receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
1.54 – 1.6 Mb

Chr 3:
15.37 – 15.43 Mb

PubMed search

[1]

[2]

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.^[1]^[2]^[3] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.^[3]

Interactions [link]

SIRPB1 has been shown to interact with TYROBP.^[4]^[5]

References [link]

^ Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J, Ullrich A (April 1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature 386 (6621): 181–6. DOI:10.1038/386181a0. PMID 9062191.
^ van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (December 2005). "A nomenclature for signal regulatory protein family members". J Immunol 175 (12): 7788–9. PMID 16339511.
^ ^a ^b "Entrez Gene: SIRPB1 signal-regulatory protein beta 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10326.
^ Dietrich, J; Cella M, Seiffert M, Bühring H J, Colonna M (January 2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. (UNITED STATES) 164 (1): 9–12. ISSN 0022-1767. PMID 10604985.
^ Tomasello, E; Cant C, Bühring H J, Vély F, André P, Seiffert M, Ullrich A, Vivier E (August 2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. (GERMANY) 30 (8): 2147–56. DOI:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. ISSN 0014-2980. PMID 10940905.

Further reading [link]

Dietrich J, Cella M, Seiffert M, et al. (2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells.". J. Immunol. 164 (1): 9–12. PMID 10604985.
Tomasello E, Cant C, Bühring HJ, et al. (2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12.". Eur. J. Immunol. 30 (8): 2147–56. DOI:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. PMID 10940905.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052.
Cannon JP, Haire RN, Litman GW (2002). "Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate.". Nat. Immunol. 3 (12): 1200–7. DOI:10.1038/ni849. PMID 12415263.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. DOI:10.1101/gr.2435604. PMC 515316. PMID 15342556. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Liu Y, Soto I, Tong Q, et al. (2006). "SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration". J. Biol. Chem. 280 (43): 36132–40. DOI:10.1074/jbc.M506419200. PMID 16081415.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. DOI:10.1021/pr0502065. PMC 1850943. PMID 16335952. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850943.

PDB gallery

2d9c: Solution structure of the first ig-like domain of signal-regulatory protein beta-1 (SIRP-beta-1)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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Interactions [link]

References [link]

Further reading [link]

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