SIG plc

SIG plc is a British-based international supplier of insulation, roofing, commercial interiors and specialist construction products. It is listed on the London Stock Exchange and is a constituent of the FTSE 250 Index.

History

The Company was founded by Ernest Adsetts in 1957 Sheffield as Sheffield Insulations Limited. His son Norman Adsetts joined the firm in 1966 becoming Managing Director in 1970 and then Chairman in 1985. The Company was first listed on the London Stock Exchange in 1989 when it became Sheffield Insulations Group plc.

The Company expanded rapidly in the early 1990s acquiring Ceilings Distribution Ltd, a UK supplier of ceilings products, in 1990, Freeman Group, a large British insulation distributor, and Isokauf in Germany in 1994 and Komfort Systems, a supplier of partition systems for offices, in 1995.

The Company was renamed SIG plc in 1995.Norman Adsetts retired the following year.

Acquisitions in the late 1990s included WKT and Golinski of Germany in 1996, and Asphaltic, a major UK roofing supplier, CP Supplies and Branton Industries and Distribution International in the USA in 1997.

Public limited company

A public limited company (legally abbreviated to plc) is a type of public company (publicly held company) under United Kingdom company law, some Commonwealth jurisdictions, and the Republic of Ireland. It is a limited (liability) company whose shares may be freely sold and traded to the public (although a plc may also be privately held, often by another plc), with a minimum share capital of £50,000 and the letters PLC after its name. Similar companies in the United States are called publicly traded companies.

A PLC can be either an unlisted or listed company on the stock exchanges. In the United Kingdom, a public limited company usually must include the words "public limited company" or the abbreviation "PLC" or "plc" at the end and as part of the legal company name. Welsh companies may instead choose to end their names with ccc, an abbreviation for cwmni cyfyngedig cyhoeddus. However, some public limited companies (mostly nationalised concerns) incorporated under special legislation are exempted from bearing any of the identifying suffixes. The term "public limited company" and the "PLC"/"plc" suffix were introduced in 1974; prior to this, all limited companies bore the suffix "Limited" ("Ltd"), which is still used by private limited companies.

PLCG1

Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene.

Function

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RASGRP1 to translocate to the Golgi apparatus, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. The receptor protein tyrosine phosphatase PTPmu (PTPRM) is capable of dephosphorylating PLCG1. Two transcript variants encoding different isoforms have been found for this gene.

Has been shown to interact with CISH which negatively regulates it by targeting it for degradation. The deletion of Cish in effector T cells has been shown to augment TCR signaling and subsequent effector cytokine release, proliferation and survival. The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant increase in functional avidity and long-term tumor immunity. There are no changes in activity or phosphorylation of Cish's purported target, STAT5 in either the presence or absence of Cish.

Phosphoinositide phospholipase C

Phosphoinositide phospholipase C (PLC) (EC 3.1.4.11, triphosphoinositide phosphodiesterase, phosphoinositidase C, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, PI-PLC, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase) is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. These enzymes belong to a larger superfamily of Phospholipase C. Other families of phospholipase C enzymes have been identified in bacteria and trypanosomes. Phospholipases C are phosphodiesterases.

Phospholipase Cs participate in phosphatidylinositol 4,5-bisphosphate (PIP₂) metabolism and lipid signaling pathways in a calcium-dependent manner. At present, the family consists of six sub-families comprising a total of 13 separate isoforms that differ in their mode of activation, expression levels, catalytic regulation, cellular localization, membrane binding avidity and tissue distribution. All are capable of catalyzing the hydrolysis of PIP₂ into two important second messenger molecules, which go on to alter cell responses such as proliferation, differentiation, apoptosis, cytoskeleton remodeling, vesicular trafficking, ion channel conductance, endocrine function and neurotransmission.

Sig

Sig may refer to:

The acronym SIG may stand for:

Jak and Daxter

Jak and Daxter is a video game franchise created by Andy Gavin and Jason Rubin and owned by Sony Computer Entertainment. The series was developed by Naughty Dog with a number of installments being outsourced to Ready at Dawn and High Impact Games. The first entry was one of the earliest titles released on the PlayStation 2, and is regarded as a defining franchise for the console.

The games are considered story-based platformers that feature a mixture of action, racing and puzzle solving. The series is set in a fictional universe that incorporates science fantasy elements, and centers on the titular characters as they try to uncover the secrets of their world, and unravel the mysteries left behind by an ancient race of Precursors.

The first three games in the series were re-released on the PlayStation 3 and PlayStation Vita as part of a remastered collection that includes support for the PlayStation Network and the PlayStation Suite. The remastered collection was handled by Mass Media Inc. with Naughty Dog assisting with the conversion of the games. The series has also produced various forms of extended media and merchandise, and has sold over 12 million copies worldwide.

.357 SIG

The .357 SIG pistol cartridge (designated as the 357 Sig by the SAAMI and 357 SIG by the C.I.P.) is the product of Swiss-German firearms manufacturer SIG Sauer, in cooperation with American ammunition manufacturer Federal Cartridge. While it is based on a .40 S&W case necked down to accept 0.355-inch (9.0 mm) bullets, the .357 SIG brass is slightly longer by 0.009 in (0.23 mm) to 0.020 in (0.51 mm) total. The cartridge is used by a number of law enforcement agencies and has a good reputation for both accuracy and stopping power.

History

Developed in 1994, the new cartridge was named "357" to highlight its purpose: to duplicate the performance of 125-grain (8.1 g) .357 Magnum loads fired from 4-inch (100 mm) barreled revolvers, in a cartridge designed to be used in a semi-automatic pistol with greater ammunition capacity than a revolver. Performance is similar to the 9×23mm Winchester.

Other than specialized competition cartridges like the 9×25mm Dillon (1988), which necked a 10mm Auto case down to a 9mm bullet, the .357 SIG (1994) was the first modern bottleneck commercial handgun cartridge since the early 1960s, when Winchester introduced a .257 caliber round based on the .357 Magnum, the now obsolete .256 Winchester Magnum (1960). Then Remington introduced the unsuccessful .22 Remington Jet (1961), which necked a .357 Magnum case down to a .22 caliber bullet, and the .221 Remington Fireball (1963), a shortened version of their .222 Remington. Soon after the .357 SIG, other bottleneck commercial handgun cartridges appeared: the .400 Corbon (1996), necking the .45 ACP down to .40 caliber; the .440 Corbon (1998), necking down the .50 AE to .44 caliber; the .32 NAA (2002), necking the .380 ACP down to .32 caliber; and the .25 NAA (2004), necking the .32 ACP down to .25 caliber.