SIGINT Activity Designator

A SIGINT Activity Designator (or SIGAD) identifies a signals intelligence (SIGINT) line of collection activity associated with a signals collection station, such as a base or a ship. For example, the SIGAD for Menwith Hill in the UK is USD1000. SIGADs are used by the signals intelligence agencies of the United States, the United Kingdom, Canada, Australia and New Zealand.

There are several thousand SIGADs including the substation SIGADs denoted with a trailing alpha character. Several dozen of these are significant. The leaked Boundless Informant reporting screenshot showed that it summarized 504 active SIGADs during a 30-day period in March 2013.

General Format

A SIGAD consists of five to eight case insensitive alphanumeric characters. It takes the general form of an alphanumeric designator normally composed of a two- or three-letter prefix followed by one to three numbers. Often a dash is used to separate the alphabetic and numeric characters in the primary part of the designator, but less frequently a space is used as a separator or the alphabetic and numeric characters are concatenated together. An additional alphabetic character can be added to denote a sub-designator for a subset of the primary unit, such as a detachment. Lastly, a numeric character can be added after the aforementioned alphabetic to provide for a sub-sub-designator.

Selective immunoglobulin A deficiency

Selective immunoglobulin A (IgA) deficiency (SIgAD) is a genetic immunodeficiency. People with this deficiency lack immunoglobulin A (IgA), a type of antibody that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract. It is defined as an undetectable serum IgA level in the presence of normal serum levels of IgG and IgM. It is the most common of the primary antibody deficiencies.

Epidemiology

Prevalence varies by population, but is on the order of up to 1 in 333 people, making it relatively common for a genetic disease.

It is more common in males than in females.

Pathophysiology

There is an inherited inability to produce immunoglobulin A (IgA), a part of the body's defenses against infection at the body's surfaces (mainly the surfaces of the respiratory and digestive systems). As a result, bacteria at these locations are somewhat more able to cause disease.

Types include:

Symptoms and diagnosis

People with selective IgA deficiency are usually asymptomatic, but can have increased frequency of infections, particularly in the respiratory, digestive and genitourinary systems, for example, sinusitis and urinary tract infections. These infections are generally mild and would not usually lead to an in-depth workup except when unusually frequent. They may present with severe reactions including anaphylaxis to blood transfusions or intravenous immunoglobulin due to the presence of IgA in these blood products. When suspected, the diagnosis can be confirmed by laboratory measurement of IgA level in the blood. Patients have an increased susceptibility to pneumonia and recurrent episodes of other respiratory infections and a higher risk of developing autoimmune diseases in middle age.