SH3KBP1

SH3 domain-containing kinase-binding protein 1 is an enzyme that in humans is encoded by the SH3KBP1 gene.

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM]

Interactions

SH3KBP1 has been shown to interact with B-cell linker,Grb2,SH3GLB2,SH3GL3,SH3GL2,BCAR1,Epidermal growth factor receptor,CBLB,Cbl gene,SOS1,CRK and PAK2.

References

Further reading