Proposed top-level domain

The Domain Name System of the Internet consists of a set of top-level domains which constitute the root domain of the hierarchical name space and database. In the growth of the Internet, it became desirable to expand the set of initially six generic top-level domains in 1984. As a result new top-level domain names have been proposed for implementation by ICANN. Such proposals included a variety of models ranging from adoption of policies for unrestricted gTLDs that could be registered by anyone for any purpose, to chartered gTLDs for specialized uses by specialized organizations. In October 2000, ICANN published a list of proposals for top-level domain strings it had received.

Geographic proposals

SCO1

Protein SCO1 homolog, mitochondrial is a protein that in humans is encoded by the SCO1 gene. Mutations in both SCO1 and SCO2 are associated with distinct clinical phenotypes as well as tissue-specific cytochrome c oxidase deficiency. SCO1 localizes predominantly to blood vessels, whereas SCO2 is barely detectable. Expression of SCO2 is also much higher than that of SCO1 in muscle tissue, while SCO1 is expressed at higher levels in liver tissue than SCO2.

Function

Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene.

Clinical relevance

Mutation in the SCO1 gene are a cause of mitochondrial complex IV deficiency also known as cytochrome c oxidase deficiency. This disorder affects the mitochondrial respiratory chain resulting in a variety of symptoms, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. A subset of patients also suffer from Leigh syndrome.

2-methylisoborneol synthase

2-methylisoborneol synthase (EC 4.2.3.118, sco7700, 2-MIB cyclase, MIB synthase, MIBS) is an enzyme with system name (E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming). This enzyme catalyses the following chemical reaction

The product, 2-methylisoborneol, is a characteristic odiferous compound with a musty smell produced by soil microorganisms.

References

External links

Group

Group may refer to:

Groups of people

In science and technology

In mathematics

In chemistry

In computing and the internet

Other uses in science and technology

Other uses

Stratigraphic unit

A stratigraphic unit is a volume of rock of identifiable origin and relative age range that is defined by the distinctive and dominant, easily mapped and recognizable petrographic, lithologic or paleontologic features (facies) that characterize it.

Units must be mappable and distinct from one another, but the contact need not be particularly distinct. For instance, a unit may be defined by terms such as "when the sandstone component exceeds 75%".

Lithostratigraphic units

Sequences of sedimentary and volcanic rocks are subdivided on the basis of their lithology. Going from smaller to larger in scale, the main units recognised are Bed, Member, Formation, Group and Supergroup.

Bed

A bed is a lithologically distinct layer within a member or formation and is the smallest recognisable stratigraphic unit. These are not normally named, but may be in the case of a marker horizon.

Member

A member is a named lithologically distinct part of a formation. Not all formations are subdivided in this way and even where they are recognized, they may only form part of the formation.

1994 Group

The 1994 Group was a coalition of smaller research-intensive universities in the United Kingdom, founded in 1994 to defend these universities' interests following the creation of the Russell Group by larger research-intensive universities earlier that year. The 1994 Group originally represented seventeen universities, rising to nineteen, and then dropping to eleven. The Group started to falter in 2012, when a number of high performing members left to join the Russell Group. The 1994 Group ultimately dissolved in November 2013.

Role

The group sought "to represent the views of its members on the current state and the future of higher education through discussions with the government, funding bodies, and other higher education interest groups" and "[made] its views known through its research publications and in the media".

University Alliance, million+, GuildHE and the Russell Group were its fellow university membership groups across the UK higher education sector.

Members

1994 Group position in league tables