| Sodium channel, voltage-gated, type II, beta subunit | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SCN2B[] | ||||||||||||
| External IDs | OMIM: 601327 MGI: 106921 HomoloGene: 3373 ChEMBL: 5446 GeneCards: SCN2B Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6327 | 72821 | |||||||||||
| Ensembl | ENSG00000149575 | ENSMUSG00000070304 | |||||||||||
| UniProt | O60939 | Q56A07 | |||||||||||
| RefSeq (mRNA) | NM_004588.4 | NM_001014761.2 | |||||||||||
| RefSeq (protein) | NP_004579.1 | NP_001014761.1 | |||||||||||
| Location (UCSC) | Chr 11: 118.03 – 118.05 Mb |
Chr 9: 44.93 – 44.94 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Sodium channel subunit beta-2 is a protein that in humans is encoded by the SCN2B gene.[1][2]
Contents |
See also [link]
References [link]
- ^ Plummer NW, Meisler MH (May 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics 57 (2): 323–31. DOI:10.1006/geno.1998.5735. PMID 10198179.
- ^ "Entrez Gene: SCN2B sodium channel, voltage-gated, type II, beta". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6327.
Further reading [link]
- Hartshorne RP, Catterall WA (1984). "The sodium channel from rat brain. Purification and subunit composition.". J. Biol. Chem. 259 (3): 1667–75. PMID 6319405.
- Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence." (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098. https://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf.
- Isom LL, Ragsdale DS, De Jongh KS, et al. (1996). "Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif". Cell 83 (3): 433–42. DOI:10.1016/0092-8674(95)90121-3. PMID 8521473.
- Eubanks J, Srinivasan J, Dinulos MB, et al. (1997). "Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel". Neuroreport 8 (12): 2775–9. DOI:10.1097/00001756-199708180-00025. PMID 9295116.
- Bolino A, Seri M, Caroli F, et al. (1999). "Exclusion of the SCN2B gene as candidate for CMT4B". Eur. J. Hum. Genet. 6 (6): 629–34. DOI:10.1038/sj.ejhg.5200220. PMID 9887383.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. DOI:10.1101/gr.1293003. PMC 403697. PMID 12975309. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Kim DY, Ingano LA, Carey BW, et al. (2005). "Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration". J. Biol. Chem. 280 (24): 23251–61. DOI:10.1074/jbc.M412938200. PMID 15833746.
External links [link]
- SCN2B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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