Nav1.1
Nav1.1, also known as the sodium channel, voltage-gated, type I, alpha subunit (SCN1A), is a protein which in humans is encoded by the SCN1A gene.
Function
The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, chiefly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit and 2 smaller auxiliary beta subunits. Functional studies have indicated that the transmembrane alpha subunit of the brain sodium channels is sufficient for expression of functional sodium channels. Brain sodium channel alpha subunits form a gene subfamily with several structurally distinct isoforms clustering on chromosome 2q24, types I, II (Nav1.2), and III (Nav1.3). There are also several distinct sodium channel alpha subunit isoforms in skeletal and cardiac muscle (Nav1.4 and Nav1.5, respectively).
Clinical significance
Mutations in the SCN1A gene cause inherited febrile seizures and GEFS+, type 2.
Podcasts:
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Saga
by: SagaSo you won't tell me, where you've been up to now
I don't know, they've seen you come and go (oh)
You're well on your way but never leaving the chair
Playing scenes on T.V. screens
Watching widely to glimpse the full view
While the hours have their hands all over you
You say that you see me, well I see you too
I look behind, what do you find, all but an empty room
Scratching the surface and you can't get away
You've travelled far and so far you have nothing to say
[Chorus]
Scratching the surface
You better come up for air
A new experience to get you there
Scratching the surface
You better come up for air
Strapped to the media, a machine to fear
You're onto something then it slips right away
It's in your hand, follow through right in front of you
You say that you hear me, well I hear you too
My secret is no secret, outside of the tube
So you won't tell me, what you've done up to now
You're watching me, I'm watching you decide (oh)
Scratching the surface, you can't get away
You tried so hard, and so far you have nothing to say