Nav1.8
Nav1.8 is a sodium ion channel that in humans is encoded by the SCN10A gene. Nav1.8 is a sodium channel subunit.
Nav1.8 is a tetrodotoxin (TTX)-resistant voltage-gated sodium ion channel. It is expressed specifically in the dorsal root ganglion (DRG), in unmyelinated, small-diameter sensory neurons called C-fibres and is involved in the pain pathway called nociception. C-fibres can be activated by noxious thermal or mechanical stimuli and thus can carry pain messages.
The discrete locations of Nav1.8 in sensory neurons of the DRG may be the key factor in therapeutic targets for the development of new analgesics and to treat chronic pain.
Function
Voltage-gated sodium ion channels (VGSC) are essential in producing and propagating action potentials. Tetrodotoxin, a toxin found in pufferfish is able to block some VGSCs and therefore is used to distinguish the different subtypes. There are three TTX-resistant VGSC: Nav1.5, Nav1.8 and Nav1.9. Nav1.8 and Nav1.9 are both expressed in nociceptors (damage-sensing neurons). It is known that Nav1.7, Nav1.8 and Nav1.9 are located in the DRG and play an important role in maintaining chronic inflammatory pain.
Podcasts:
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by Saga
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by Ceca
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by Steppenwolf
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by Quo Vadis
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by Sicko
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by Frankie J.
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by Baby Bash
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by Monifah
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by Silversun Pickups
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by Marisa Monte
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by Da Weasel
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by DMC
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by Saeko
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by Baby Beesh
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by Baby bash & Frankie J
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by Zico
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by Gods Of Blitz
Saga
by: SagaSo you won't tell me, where you've been up to now
I don't know, they've seen you come and go (oh)
You're well on your way but never leaving the chair
Playing scenes on T.V. screens
Watching widely to glimpse the full view
While the hours have their hands all over you
You say that you see me, well I see you too
I look behind, what do you find, all but an empty room
Scratching the surface and you can't get away
You've travelled far and so far you have nothing to say
[Chorus]
Scratching the surface
You better come up for air
A new experience to get you there
Scratching the surface
You better come up for air
Strapped to the media, a machine to fear
You're onto something then it slips right away
It's in your hand, follow through right in front of you
You say that you hear me, well I hear you too
My secret is no secret, outside of the tube
So you won't tell me, what you've done up to now
You're watching me, I'm watching you decide (oh)
Scratching the surface, you can't get away
You tried so hard, and so far you have nothing to say