SCH-58261
SCH-58261 is a drug which acts as a potent and selective antagonist for the adenosine receptor A2A, with more than 50x selectivity for A2A over other adenosine receptors. It has been used to investigate the mechanism of action of caffeine, which is a mixed A1 / A2A antagonist, and has shown that the A2A receptor is primarily responsible for the stimulant effects of caffeine, but blockade of both A1 and A2A receptors is required to accurately replicate caffeine's effects in animals. SCH-58261 has also shown antidepressant and neuroprotective effects in a variety of animal models, and has been investigated as a possible treatment for Parkinson's disease.
See also
References
Podcasts:
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by Dean Martin
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by John Denver
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by Mc Lyte
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by Tino Rossi
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by B1a4
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by Red Elvises
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by Jimmy Luxury
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by Kashtin
Chee Chee oo Chee
by: Dean Martin(Chee chee-oo chee, chee chee-oo chee)
(Chee chee-oo chee, chee chee-oo chee)
Once on a tree top tall a little bird
(Chee chee-oo chee, chee chee-oo chee)
Sang out the sweetest song I ever heard
(Chee chee-oo chee, chee chee-oo chee)
(He sang to me so merrily)
(Chee chee-oo chee, chee chee-oo chee)
(The little birdie on the tree)
Life's such a lovely thing it seemed to say
(Chee chee-oo chee, chee chee-oo chee)
If you'd only sing your cares away
(Chee chee-oo chee, chee chee-oo chee)
Chee chee-oo chee so merrily it went along
(Chee chee-oo chee, chee chee-oo chee)
Chee chee-oo chee so happily his little song
(Chee chee-oo chee, chee chee-oo chee)
And so (and so) I sing (I sing)
Chee chee-oo chee the happy happy little thing
If you (if you) feel blue (feel blue)
Sing chee chee-oo chee and you can be as happy too
(Chee chee-oo chee, chee chee-oo chee)
(Chee chee-oo chee, chee chee-oo chee)
(Chee chee-oo chee, chee chee-oo chee)
Sing this happy little song
(Chee chee-oo chee, chee chee-oo chee)
(Chee chee-oo chee, chee chee-oo chee)
(Chee chee-oo chee, chee chee-oo chee)
Chee chee-oo chee
Chee chee-oo chee it sang to me so merrily
(Chee chee-oo chee, chee chee-oo chee)
Chee chee-oo chee the little birdie on the tree
(Chee chee-oo chee, chee chee-oo chee)
(If you feel blue)
Sing chee chee-oo chee, chee chee-oo chee and you can be as happy too
(Chee chee-oo chee, chee chee-oo chee)
(Chee chee-oo chee, chee chee-oo chee)
(Chee chee-oo chee, chee chee-oo chee)
Sing this happy little song