SATB2
Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene. SATB2 is a DNA-binding protein that specifically binds nuclear matrix attachment regions and is involved in transcriptional regulation and chromatin remodeling. SATB2 has been implicated as causative in the cleft or high palate of individuals with 2q32q33 microdeletion syndrome.
Function
With an average worldwide prevalence of 1/800 live births, oral clefts are one of the most common birth defects. Although over 300 malformation syndromes can include an oral cleft, non-syndromic forms represent about 70% of cases with cleft lip with or without cleft palate (CL/P) and roughly 50% of cases with cleft palate (CP) only. Non-syndromic oral clefts are considered ‘complex’ or ‘multifactorial’ in that both genes and environmental factors contribute to the etiology. Current research suggests that several genes are likely to control risk, as well as environmental factors such as maternal smoking.
Re-sequencing studies to identify specific mutations suggest several different genes may control risk to oral clefts, and many distinct variants or mutations in apparently causal genes have been found reflecting a high degree of allelic heterogeneity. Although most of these mutations are extremely rare and often show incomplete penetrance (i.e., an unaVected parent or other relative may also carry the mutation), combined they may account for up to 5% of non-syndromic oral cleft.
Podcasts:
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by Britney Spears
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by Ayumi Hamasaki
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by Tha Alkaholiks
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by Plankeye
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by John Fogerty
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by NLT
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by No Address
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by In Your Defense
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by Pokemon the First Movie Soundtrack
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by Sabrina, The Teenage Witch Soundtrack
Soda Pop
by: Britney SpearsOoh-Ooh
Ah, here we go now
Like a great boy, all my other women are insoles
We're thinkin 'bout the great exphidition as popped we chose
So here we come, throwing here
Throwing here all on the scene
Though we go
On and on
come, come follow me Britney
yeah
Mm-hmm, soda pop, watch it fizz and pop
The clock is tickin' and we can't stop (can't stop now)
Mm-hmm soda pop, bop, shu-bop
The clock is tickin and we can't stop
We might start riding to the music tonight
A clever way to get by, oh
The pops keep flowin' like its fire and ice
So give it a little blind, ooh
Mm-hmm soda pop, watch it fizz and pop (mm-hmm)
The clock is tickin and we can't stop (now)
Mm-hmm soda bop, bop shu-bop shu-bop
The clock is tickinand we can't stop
Ooh-Ooh
We have a plan, we have a definite plan
To level the vibes (vibes)
To level vibes agian (ooh-yeah)
Where ya ba-do for a superlative self, oh yeah
A wicked time to the end, oh yaeh, so
Mm-hmm soda pop, watch it fizz and pop (ooh)
The clock is tickin and we can't stop (can't stop)
Mm-hmm soda pop, bop, shu-bop shu-bop
The clock is tickin and we can't stop
So much pop we're losing, sittin watchin the clock
So turn the tables baby, let's go over top (take it to the top now)
No one else will do
I'm waiting for you
So me what'cha got, just take a pop shot
And we will never stop shu-bop, shu-bop
yeah, mm-hmm
The clock is tickin and we can't stop
Mm-hmm soda pop, bop, shu-bop shu-bop
The clockis tickin and we can't stop (can't stop)
Do it like we never have before (before, before, before)
And lovin it til we drop (we drop, ah, we drop yeah)
We'll flex tonight until they break down the door (oh yeah)
The party won't ever stop
Mm-hmm soda pop, watch it fizz and pop (no, uh yeah)
The clock is tickinand we can't stop (stop no)
Mm-hmm soda pop, bop, shu-bop shu-bop
Mm-hmm soda pop (no) watch it fizz and pop (oh)
The clock is tickin and we can't stop (can't stop)
I bet you we can pop like we've never popped it before
Why we keep commin back fdor more and more for sure (sure)
It's cool Britney when wee get down on the floor yeah
And we go
On and On until the break of dawn
Mm-hmm soda pop, watch it fizz and pop
The clock is tickin and we can't stop (ah, can't stop, no)
Mm-hmm soda pop, bop, shu-bop shu-bop (ooh yeah)
The clock is tickinand we can't stop
All we gotta do is just
Mm-hmm soda pop, watch it fizz and pop (oh yeah)
The clock is tickin and we can't stop
Oh, we're on the bend