SAP130

Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the SAP130 gene.

Function

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM]

Interactions

SAP130 has been shown to interact with:

Model organisms

Model organisms have been used in the study of SAP130 function. A conditional knockout mouse line called Sap130^{tm1a(KOMP)Mbp} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

References

Further reading