Ryanodine
Ryanodine is a poisonous alkaloid found in the South American plant Ryania speciosa (Salicaceae). It was originally used as an insecticide.
The compound has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle, and heart muscle cells. It binds with such high affinity to the receptor that it was used as a label for the first purification of that class of ion channels and gave its name to it.
At nanomolar concentrations, ryanodine locks the receptor in a half-open state, whereas it fully closes them at micromolar concentration. The effect of the nanomolar-level binding is that ryanodine causes release of calcium from calcium stores as the sarcoplasmic reticulum in the cytoplasm, leading to massive muscular contractions. The effect of micromolar-level binding is paralysis. This is true for both mammals and insects.
See also
References
Podcasts:
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Ronnie Dunn
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by Randy Owen
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by Randy Owen
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by Randy Owen
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by Randy Owen
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by Randy Owen
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by Randy Owen
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by Randy Owen
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by Randy Owen
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by Randy Owen
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by Randy Owen
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by Ray Anthony
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by Ryandan
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by Ryandan
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by Ryandan
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by Ryandan
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by Ryandan
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by Ryandan
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by Ryandan
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by Randane
She's Actin' Single, I'm Drinkin' Double
by: Ronnie DunnSongwriter: Thompson, Wayne Carson
I've seen men look at her before
They think I don't see
I'd like to think it makes me proud
But I'm only foolin' me
I know she'll be lookin' back
The minute I'm not there
While she pours herself on some stranger
I'll pour myself a drink somewhere
She's actin' single, I'm drinkin' double
I hide my pain, I drown my troubles
My heart is breaking like tiny bubbles
She's actin' single, I'm drinkin' double
I know what she plans to do
But I don't know where or when
If I ask her who that stranger was,
She'll just say, "An old friend"
"I'm not weak," I tell myself
I stay because I'm strong
Truth is I'm not man enough
To stop her from doing me wrong
She's actin' single, I'm drinkin' double
I hide my pain, I drown my troubles
My heart is breaking like tiny bubbles
She's actin' single, I'm drinkin' doubles
She's actin' single, I'm drinkin' doubles
I hide my pain, I drown my troubles
My heart is breaking like tiny bubbles
She's actin' single, I'm drinkin' doubles