Run (Amy Macdonald song)

"Run" is the fifth single to be released from Amy Macdonald's debut album, This Is the Life. The single was released in the UK on 3 March 2008 and peaked at #75 in the United Kingdom for 1 week. Macdonald stated on stage at T in the Park 2008 that the song was inspired by a gig by The Killers in her hometown of Glasgow.

Track listing

2-Track

Maxi (Germany)

Music video

The music video for "Run" features Macdonald walking through a forest at night.

Charts

Macdonald's single "Run" was released on 3 March and jumped in the top 75 at number 75,next week it was knocked out of the top 75. Run charted at #36 in Germany.

References

External links

Run 2

"Run 2" was New Order's third and final single from their 1989 album Technique. The album version was listed as simply "Run".

Overview

"Run 2" was remixed by Scott Litt from the version on Technique, hence the appendage of "2" to the title. The main difference is that the song has been made more radio-friendly by editing down most of the long instrumental run-out and appending it with a final repeat of the chorus. Litt's mix strips back much of the echo and layers of synthesizers, and in place centres the mix on Sumner's vocal and the bass guitar of Peter Hook. Despite the effort taken to produce a radio single, only 20,000 of the Factory 12" release were ever pressed. 500 7-inch records were also pressed, for promotional use. The single was only released in the UK.

John Denver's publishing company filed a lawsuit, alleging that the guitar break in "Run" too closely resembled Denver's "Leaving on a Jet Plane". The case was settled out of court. The song has since been credited to New Order and John Denver.

Run (novel)

Run is a 2007 novel by American author Ann Patchett. It was her first novel after the widely successful Bel Canto (2001).

Plot summary

This novel tells the story of Bernard Doyle, an Irish Catholic Boston politician. He and wife Bernadette have one biological son and later adopt African-American brothers Tip and Teddy. (The adoptees' names were given to them by the Doyles as a tribute to the Massachusetts politicians Thomas "Tip" O'Neill and Edward "Teddy" Kennedy.) Four years later, Doyle loses Bernadette to cancer. Sixteen years after his wife's death, Tip and Teddy are university students. Bernard, the former mayor of Boston, has invited them to a Jesse Jackson lecture and a reception afterward. Tip is pushed out of the path of an oncoming vehicle by a woman the family believes is a stranger. The novel's plot centers around that woman's identity and that of her 11-year-old daughter Kenya, who comes to stay with the Doyles. Interracial adoption, family allegiances and rivalries, and Boston’s notoriously complex political and racial history come into play, as does the role of religious faith in each family member's life.

ADD1

Alpha-adducin is a protein that in humans is encoded by the ADD1 gene.

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Polymorphism in ADD1 is associated with hypertension.

References

Further reading

ADD3

Gamma-adducin is a protein that in humans is encoded by the ADD3 gene.

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is composed of two distinct domains. The amino-terminal region is protease-resistant and globular in shape, while the carboxy-terminal region is protease-sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.

ADD2

Beta-adducin is a protein that in humans is encoded by the ADD2 gene.

Function

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues.

While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is composed of two distinct domains.

The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Various adducin beta mRNAs, alternatively spliced at 3'end and/or internally spliced and encoding different isoforms, have been described. The functions of all the different isoforms are not known.

Free

Media

Arts and philosophy

Computing

Mathematics