(–)-2β-Carbomethoxy-3β-(4-tolyl)tropane (RTI-32, tolpane) is a phenyltropane-based cocaine analog that is important in the field of medicinal chemistry for performing SAR.
It has similar properties in vitro to related drugs such as RTI-31.
Whereas the potency of RTI-31 has been quoted as being as high as 64 x cocaine, RTI-32 is not anything like this strong.
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RTI or Rti may refer to:
Rti is a village in the municipality of Lučani, Serbia. According to the 2002 census, the village has a population of 553 people.
(–)-2β-Carbophenoxy-3β-(p-tolyl)tropane (RTI-120) is a phenyltropane derivative which acts as a reasonably selective dopamine reuptake inhibitor, along with weaker inhibition of noradrenaline and serotonin reuptake. It has a reasonably fast rate of occupancy of dopamine transporters in the brain, though slower than that of cocaine itself. RTI-120 has a short duration of action, along with other p-methyl substituted phenyltropanes such as RTI-150, RTI-171 and RTI-199, giving it a more similar pharmacological profile to cocaine compared to longer acting analogues like RTI-121 and RTI-177.