Roanoke /ˈroʊ.ənoʊk/ may refer to:
The Roanoke, also spelled Roanoac, tribe were a Carolina Algonquian-speaking people whose territory comprised present-day Dare County, Roanoke Island and part of the mainland at the time of English exploration and colonization. They were one of the numerous Carolina Algonquian tribes, which may have numbered 5,000-10,000 people in total in eastern North Carolina at the time of English encounter.
The last known chief of the Roanoke was Wanchese, who traveled to England with colonists in 1584. The smaller Croatan people may have been a branch of the Roanoke or a separate tribe allied with it.
The Roanoke may have had their capital on the western shore of Croatan Sound, at Dasamonguepeuk. This was one of the significant towns noted by the English colonists in the sixteenth century.
Numerous place names were derived from the Roanoke.
Roanoke station is a train station that will serve Amtrak's Northeast Regional service beginning in late 2016 or early 2017. The station is also a proposed regional rail staffed station along the Transdominion Express in Roanoke, Virginia.
The station will connect Roanoke by passenger rail for the first time since 1979.