Rnd3
Rnd3 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND3.
Like other members of the Rho family of Ras-related GTPases it regulates the organization of the actin cytoskeleton in response to extracellular growth factors.
Regulation
Like Ras, Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex (see MIM 601925); GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins (see MIM 601855); and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form (see MIM 602680) (Nobes et al., 1998).[supplied by OMIM]
Interactions
Rnd3 has been shown to interact with ARHGAP5 and UBXD5.
References
Further reading
Podcasts:
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by Wu-Tang Clan
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by Ol' Dirty Bastard
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by Peaches
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by 911
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by Broken Hope
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by Peaches & Herb
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by Falamansa
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by Trip
Reunited
by: Wu-Tang ClanEverybody it's Wu motherfuckers, Wu Tang motherfuckers
It's Wu motherfuckers, Wu Tang motherfuckers
It's Wu motherfuckers, Wu Tang motherfuckers
It's Wu motherfuckers
Reunited double LP we're all excited
Struck a match to the underground industry ignited
From metaphorical parables to fertilize the earth
Wicked niggaz come try to burglarize the turf
Scattin' off soft-ass beats them niggaz rap happily
Tragically, that style, deteroiate, rapidly
Uncompleted missions to best known competitions
You couldn't add it up, if you mastered addition
Where I come from, gettin' visual is habitual
Demonstrate walkin' on hot coal, in rituals
I splash the paint on the wall formed the mural
Took a look shot the manifestation of it was plural
Rhymin' while impaired, dart hit your garment
Pierced your internal streamlined compartments
Just consider the unparallel advantage
With all D P that's impossible to manage
Bitch ass niggaz counterfeit the funk
I smoke the bead and the skunk tree top of the trunk
Moonshine drunken monk you get shrunk
The touch of skunk I be fuckin' bitches by the chunk
My name black do words wanna play in my dirt?
Bitch stop my momma serve free lunch from the church
I come like a thousand doves
Bitch she's crazy at the bus makin' the fun I gots tough love
Unglove the news watch a niggaz transfuse
Dirty add to the fuse heavy at the booze
I don't walk I get carried
Gold and platinum frisbees on my wall lookin' properly
I do it for you Wright Brothers
The Indian that sold Manhattan to the man
My grandfather step up and get knocked right the fuck out
Come to the cook out dirty bitch at the mouth
You scared? Run around like a plane about to crash
Wu Tang motherfuckers
Wu Tang motherfuckers
Wu Tang motherfuckers
The riddler funny bone tickler freak Caligula
Bigger dick sex enigma, fertilize your stigma
Stink box order from pink dot
MC's get stuck on ink blots as I plug to the sink box
Wu Tang in corp your brain on spacewalk
Talk strange like Bjork great hero Jim Thorpe
How can I put it? It's like my video footage
Hard to edit my niggaz that never understood it
I'm too impulsive my dosage it's hard for you nigga to notice
I come through your postage
I don't play the rap souflee for the day
Ruler zig-zag-zig a, leg leg arm head
Spread like plague we drink Hennessee by the keg
I got the golden egg plus the goose
Eighty proof absolute CC mixed with fruit juice, motherfucker
I got yo' neck in a noose
It's Wu motherfuckers, Wu Tang motherfuckers