Ripatransone is a comune (municipality) in the Province of Ascoli Piceno in the Italian region Marche, located about 70 kilometres (43 mi) southeast of Ancona and about 20 kilometres (12 mi) northeast of Ascoli Piceno.
The hill of Ripatransone (whose name means "Rupes of Transone", a local feudatary who founded the castle here) was inhabited since prehistorical times, and was settled first by the Umbri and then the Piceni. After the Roman conquest it lost importance, regaining it in the Middle Ages when several castles were built here, being unified into a single town in 1096. In 1205 it was a free commune, existing in particular rivalry with Fermo and against Francesco Sforza. In 1571 it was given the status of City and that of diocesan see by Pope Pius V. After the Renaissance it was part of the Papal States, becoming part of unified Italy in 1860.