MRE11A

Double-strand break repair protein MRE11A is a protein that in humans is encoded by the MRE11A gene.

Function

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Orthologs of MRE11A

Mre11, an ortholog of human MRE11A, occurs in the prokaryote archaeon Sulfolobus acidocaldarius. In this organism the Mre11 protein interacts with the Rad50 protein and appears to have an active role in the repair of DNA damages experimentally introduced by gamma radiation. Similarly, during meiosis in the eukaryotic protist Tetrahymena Mre11 is required for repair of DNA damages, in this case double-strand breaks, by a process that likely involves homologous recombination. These observations suggest that human MRE11A is descended from prokaryotic and protist ancestral Mre11 proteins that served a role in early processes for repairing DNA damage.

Meal, Ready-to-Eat

The Meal, Ready-to-Eat – commonly known as the MRE – is a self-contained, individual field ration in lightweight packaging bought by the United States military for its service members for use in combat or other field conditions where organized food facilities are not available. The MRE replaced the canned MCI, or Meal, Combat, Individual rations, in 1981, and is the intended successor to the lighter LRP ration developed by the United States Army for Special Forces and Ranger patrol units in Vietnam.

History

The first soldier ration established by a Congressional Resolution, during the Revolutionary War, consisted of enough food to feed a man for one day, mostly beef, peas, and rice. During the Civil War, the military moved toward canned goods. Later, self-contained kits were issued as a whole ration and contained canned meat, pork, bread, coffee, sugar and salt. During the First World War, canned meats were replaced with lightweight preserved meats (salted or dried) to save weight and allow more rations to be carried by soldiers carrying their supplies on foot. At the beginning of World War II, a number of new field rations were introduced, including the Mountain ration and the Jungle ration. However, cost-cutting measures by Quartermaster Command officials during the latter part of World War II and the Korean War again saw the predominance of heavy canned C rations issued to troops, regardless of operating environment or mission. The use of canned wet rations continued through the Vietnam War, with the improved MCI field ration.

Ride (1998 film)

Ride is a 1998 American comedy film written and directed by Millicent Shelton. The film stars Malik Yoba, Fredro Starr, and Melissa De Sousa. The film is sometimes confused with The Ride, another film released in 1998.

Plot

NYC film school graduate Leta Evans (De Sousa) has just become the assistant to hot music video director Bleau Kelly (Downtown Julie Brown). She almost loses the job before her first day's barely even started when Bleau decides budget cuts must be made for her next project. When Leta offers to do the assignment for a smaller fee, Bleau decides to have her escort a group of rappers, singers, and showbiz wanna-be's to Miami for a video shoot. The gang, which is kept in line by Poppa (Yoba), gets acquainted on a decaying bus as they travel down the East Coast, encountering barroom fights and other problems en route to the video gig.

Cast

Ride (The Vines song)

"Ride" was the second official single from The Vines' second album, Winning Days. Although it wasn't a big chart success, "Ride" is one of the band's best known songs because it was featured in a number of advertisements, including commercials for Apple's iPod, Nissan, American Chopper, NASCAR Hot Pass, WKCF, The WB, and Split Second: Velocity. Written by Craig Nicholls.

This song was also featured on an episode of America's Funniest Home Videos in 2006 during a montage of motorcycle accidents and in the "Best Movie" montage at the 2004 MTV Movie Awards for nominee Pirates of the Caribbean: The Curse of the Black Pearl. "Ride" along with "Get Free" were featured in the documentary Warren Miller's Impact.

In Australia, the song was ranked #94 on Triple J's Hottest 100 of 2004.

Track listing

CD single

Vinyl single

Music video

The "Ride" music video, directed by Michel Gondry, shows the band playing by themselves in a hall. When they get to the chorus, bands appear from everywhere, helping them sing and play.

Ride (Ciara song)

"Ride" is a song performed by American recording artist Ciara. The song features American rapper Ludacris. It was co-written by Ciara, Ludacris, Tricky Stewart, and The-Dream, and produced by the latter two. The song serves as the lead single from her fourth studio album, Basic Instinct. The song was first released for digital download on April 23, 2010. "Ride" is a down-tempo R&B song, featuring a heavy bass line and seductive tone.

The song received generally positive reviews from critics, complimenting the song's toned-down production. It reached three on the Hot R&B/Hip-Hop Songs in the United States, becoming Ciara's twelfth top ten hit on the chart. The accompanying music video features sexually charged, provocative choreography, and therefore was not aired on BET, and banned from UK music channels. The official remix features André 3000 and Bei Maejor in addition to Ludacris.

Background

Jive Records spoke exclusively to Rap Up magazine on March 29, 2010 to confirm that Ciara would be releasing a new song called "Ride" featuring Ludacris. It is the fourth time that the two artists have collaborated: the first being 2005's "Oh", second being 2009's "High Price" and the third being the 2010 remix to Ludacris' single "How Low".

Pony (Kasey Chambers song)

"Pony" is a country song written by Kasey Chambers and produced by Nash Chambers for Kasey Chambers third album Wayward Angel (2004). It was released as the album's third single on 16 January 2005 in Australia as CD single. The song became Chambers' third top ten hit in Australia and includes a reference to Ralph Stanley, the Folk, Bluegrass, and Country music legend.

Track listing

All songs written and composed by Kasey Chambers. 

Charts

References

External links

Ed Gass-Donnelly

Ed Gass-Donnelly (born August 17, 1977 in Toronto, Ontario) is an award-winning Canadian film director, screenwriter and producer. His first full-length film, This Beautiful City, was released in 2008 and nominated for four Genies at the 29th Genie Awards. In January 2011 Gass-Donnelly was selected as one of the top ten film makers to watch by Variety.

Filmography

References

External links