Renin
Renin (etymology and pronunciation), also known as an angiotensinogenase, is an enzyme that participates in the body's renin-angiotensin aldosterone system (RAAS)—also known as the renin-angiotensin-aldosterone axis—that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. Thus, it regulates the body's mean arterial blood pressure.
Renin is often improperly referred to as a hormone even though it has no peripheral receptors and rather has an enzymatic activity with which it hydrolyzes angiotensinogen to angiotensin I.
Biochemistry and physiology
Structure
The primary structure of renin precursor consists of 406 amino acids with a pre- and a pro-segment carrying 20 and 46 amino acids, respectively. Mature renin contains 340 amino acids and has a mass of 37 kDa.
Secretion
The enzyme renin is secreted by the afferent arterioles of the kidney from specialized cells of the juxtaglomerular apparatus – the juxtaglomerular cells, in response to three stimuli:
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Life Is A Rock
by: ReunionB.B. Bumble and the Stingers, Mott the Hoople, Ray Charles Singers
Lonnie Mack and twangin' Eddy, here's my ring we're goin' steady
Take it easy, take me higher, liar liar, house on fire
Locomotion, Poco, Passion, Deeper Purple, Satisfaction
Baby baby gotta gotta gimme gimme gettin' hotter
Sammy's cookin', Lesley Gore and Ritchie Valens, end of story
Mahavishnu, fujiyama, kama-sutra, rama-lama
Richard Perry, Spector, Barry, Archies, Righteous, Nilsson, Harry
Shimmy shimmy ko-ko bop and Fats is back and Finger Poppin'
Life is a rock but the radio rolled me
Gotta turn it up louder, so my DJ told me (whoa whoa whoa whoa)
Life is a rock but the radio rolled me
At the end of my rainbow lies a golden oldie
FM, AM, hits are clickin' while the clock is tock-a-tickin'
Friends and Romans, salutations, Brenda and the Tabulations
Carly Simon, I behold her, Rolling Stones and centerfoldin'
Johnny Cash and Johnny Rivers, can't stop now, I got the shivers
Mungo Jerry, Peter Peter Paul and Paul and Mary Mary
Dr. John the nightly tripper, Doris Day and Jack the Ripper
Gotta go Sir, gotta swelter, Leon Russell, Gimme Shelter
Miracles in smokey places, slide guitars and Fender basses
Mushroom omelet, Bonnie Bramlett, Wilson Pickett, stop and kick it
Life is a rock but the radio rolled me
Gotta turn it up louder, so my DJ told me (whoa whoa whoa whoa)
Life is a rock but the radio rolled me
At the end of my rainbow lies a golden oldie
Arthur Janov's primal screamin', Hawkins, Jay and
Dale and Ronnie, Kukla, Fran and Norma Okla
Denver, John and Osmond, Donny
JJ Cale and ZZ Top and LL Bean and De De Dinah
David Bowie, Steely Dan and sing me prouder, CC Rider
Edgar Winter, Joanie Sommers, Osmond Brothers, Johnny Thunders
Eric Clapton, pedal wah-wah, Stephen Foster, do-dah do-dah
Good Vibrations, Help Me Rhonda, Surfer Girl and Little Honda
Tighter, tighter, honey, honey, sugar, sugar, yummy, yummy
CBS and Warner Brothers, RCA and all the others
Life is a rock but the radio rolled me
Gotta turn it up louder, so my DJ told me (whoa whoa whoa whoa)
Life is a rock but the radio rolled me
At the end of my rainbow lies a golden oldie
spoken:
Listen--remember, they're playing our song!
Rock it, sock it, Alan Freed me, Murray Kaufman, try to leave me
Fish, and Swim, and Boston Monkey,
Make it bad and play it funky.
(Wanna take you higher!)