Regeneration
Regeneration is renewal through the internal processes of a body or system. Something which embodies this action can be described as regenerative. Many titles of cultural work and cultural and scientific concepts use the term, and may refer to:
Science and technology
History
Music
Film and television
Resident Evil
Resident Evil, known as Biohazard (バイオハザード, Baiohazādo) in Japan, is an action, adventure, horror fiction video game based media franchise created by Shinji Mikami and owned by the video game company Capcom. The franchise focuses around a series of survival horror video games, but has since branched out into comic books, novels and novelizations, sound dramas, a series of live-action films and animated sequels to the games, and a variety of associated merchandise, such as action figures. The overarching plot of the series focuses on multiple characters and their roles in recurring outbreaks of zombies and other monsters, initially due to the release of the T-virus, a biological weapon created by the fictional Umbrella Corporation.
The eponymous first game in the series was released in 1996 as a survival horror video game, but the franchise has since grown to encompass other video game genres. The series is a mix of action and horror film-inspired plotlines, exploration and puzzle solving, but from Resident Evil 4 onwards, the main series took a more third-person shooter approach with fewer puzzles and greater emphasis on gunplay and weapons upgrading. As of 2015, the video game series has sold 61 million units worldwide. It has become Capcom's biggest franchise in terms of sales and marked the start of the "survival horror" genre, which was already influenced by earlier efforts such as Sweet Home (also by Capcom) and the Alone in the Dark series.
BTK
BTK may refer to:
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Birth Through Knowledge
Birth Through Knowledge (aka BTK) was a Canadian hip-hop/rock band best known for their 1998 single "Peppyrock," the video for which was nominated for the 1998 MuchMusic Best Video Award. The band consisted of Lo-Ki (vocals), Stone Groove (vocals), DJ Spinz (turntables), Adam Carlo (bass),Sam Cino (drums,percussion) and Matt deMatteo (drums).
After signing onto the Tommyboy/Ignition label, BTK released one album "Birth Thru Knowledge" in 1998.
BTK first came to attention when their song "Corncob Pipe" was included on the sampler disc that Korn released alongside Follow the Leader. They were the first indie band to ever open the main-stage at Edgefest '97. In 1998, the band toured with the Beastie Boys and with Our Lady Peace. They appeared in the 1998 Summersault tour.
The band won the 1997 MuchMusic Best Independent Video Award for "Superchile." They were also nominated for a Juno Award in 1999 in the Best Alternative Album category, losing to Rufus Wainwright.
Footnotes
Bruton's tyrosine kinase
Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development.
Function
BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor.
Btk contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP2, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling.
Clinical significance
Mutations in the BTK gene are implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia). Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified.
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