ADD1

Alpha-adducin is a protein that in humans is encoded by the ADD1 gene.

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Polymorphism in ADD1 is associated with hypertension.

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Further reading

ADD3

Gamma-adducin is a protein that in humans is encoded by the ADD3 gene.

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is composed of two distinct domains. The amino-terminal region is protease-resistant and globular in shape, while the carboxy-terminal region is protease-sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.

ADD2

Beta-adducin is a protein that in humans is encoded by the ADD2 gene.

Function

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues.

While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is composed of two distinct domains.

The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Various adducin beta mRNAs, alternatively spliced at 3'end and/or internally spliced and encoding different isoforms, have been described. The functions of all the different isoforms are not known.

Robot (disambiguation)

A robot is a virtual or mechanical artificial agent, usually an electro-mechanical machine.

Robot or Robots may also refer to:

Computing

Film and television

Music

Robot Face

<|°_°|>, also known as Robot Face, is the third studio album by electro swing group Caravan Palace, released on 16 October 2015.

Track listing

Charts

References

Robot (Doctor Who)

Robot is the first serial of the 12th season in the British science fiction television series Doctor Who, which was first broadcast in four weekly parts from 28 December 1974 to 18 January 1975. It was the first full serial to feature Tom Baker as the Fourth Doctor, as well as Ian Marter as new companion Harry Sullivan.

Plot

Following his third regeneration, the Doctor briefly becomes delirious and then falls unconscious in front of Sarah Jane Smith and Brigadier Lethbridge-Stewart of UNIT. The Brigadier has Lieutenant Harry Sullivan take the Doctor into his care. Soon, the Doctor wakes, eludes Harry, and tries to sneak off in his TARDIS, but the Brigadier and Sarah Jane stop him, convincing him to help in finding the culprit in the theft of top secret plans for a disintegrator gun. The Brigadier takes the Doctor to the Ministry of Defence advanced research centre where the plans were stored, where the Doctor observes crushed flowers and a rectangular footprint. UNIT sets to protect factories where critical parts for the gun are manufactured, but find the culprit is able to outwit them, including burrowing up underground to collect the final component necessary for the weapon.

Product Red

Product Red, styled as (PRODUCT)^RED, is a licensed brand that seeks to engage the private sector in raising awareness and funds to help eliminate HIV/AIDS in Africa. It is licensed to partner companies including Nike, American Express (UK), Apple Inc., The Coca-Cola Company, Starbucks, Converse, Electronic Arts, Head, Bugaboo, Penguin Classics (UK & International), Gap, Armani, Hallmark (US), SAP and Beats Electronics (Beats by Dr. Dre). The concept was founded in 2006 by U2 frontman and activist, Bono, together with Bobby Shriver of the ONE/DATA. The Global Fund to Fight AIDS, Tuberculosis and Malaria is a recipient of (RED) money.

As part of a new business model, each partner company creates a product with the Product Red logo. In return for the opportunity to increase revenue through the Product Red license, a 50 percent of the profit gained by each partner is donated to the Global Fund. As Product Red is a private company, a portion of the contributions received from the partner brands is assigned as profit. Such an amalgamation of humanitarian aid and for-profit businesses is one example of "ethical consumerism."