Bruton's tyrosine kinase
Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development.
Function
BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor.
Btk contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP2, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling.
Clinical significance
Mutations in the BTK gene are implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia). Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified.
Isochrony
Isochrony is the postulated rhythmic division of time into equal portions by a language. Rhythm is an aspect of prosody, others being intonation, stress and tempo of speech.
Three alternative ways in which a language can divide time are postulated:
The idea as such was first expressed by Kenneth L. Pike in 1945, though the concept of language naturally occurring in chronologically and rhythmically equal measures is found at least as early as 1775 (in Prosodia Rationalis). This has implications for language typology: D. Abercrombie claimed "As far as is known, every language in the world is spoken with one kind of rhythm or with the other ... French, Telugu and Yoruba ... are syllable-timed languages, ... English, Russian and Arabic ... are stress-timed languages'. While many linguists find the idea of different rhythm types appealing, empirical studies have not been able to find acoustic correlates of the postulated types, calling into question the validity of these types.
Rhythm (song)
"Rhythm" (リズム) is Japanese singer-songwriter Ua's fifth single, released on September 24, 1996. It served as ending theme for the TBS TV program Face. It sold 17,800 copies in its first week, debuting at #20 on the Oricon Weekly Singles Chart and becoming Ua's second top 20 entry.
Track listing
CD
All lyrics written by Ua.
Vinyl
Charts and sales
References
External links
Product Red
Product Red, styled as (PRODUCT)RED, is a licensed brand that seeks to engage the private sector in raising awareness and funds to help eliminate HIV/AIDS in Africa. It is licensed to partner companies including Nike, American Express (UK), Apple Inc., The Coca-Cola Company, Starbucks, Converse, Electronic Arts, Head, Bugaboo, Penguin Classics (UK & International), Gap, Armani, Hallmark (US), SAP and Beats Electronics (Beats by Dr. Dre). The concept was founded in 2006 by U2 frontman and activist, Bono, together with Bobby Shriver of the ONE/DATA. The Global Fund to Fight AIDS, Tuberculosis and Malaria is a recipient of (RED) money.
As part of a new business model, each partner company creates a product with the Product Red logo. In return for the opportunity to increase revenue through the Product Red license, a 50 percent of the profit gained by each partner is donated to the Global Fund. As Product Red is a private company, a portion of the contributions received from the partner brands is assigned as profit. Such an amalgamation of humanitarian aid and for-profit businesses is one example of "ethical consumerism."
Red (T'Pau album)
Red is the fourth studio album by British pop/rock group T'Pau. It was released in 1998, and was the first album since The Promise from 1991.
The group originally gained success in the late 1980s and split in the early 1990s. In 1997 original lead singer Carol Decker reformed the band with a completely new line-up and released a brand new version of their original hit "Heart and Soul". The new line-up started playing gigs and recorded this album in 1998. The album was released on Decker's own Gnatfish label, and would be released in America during late 1999 with a bonus CD featuring three extra tracks (including the 1997 version of "Heart and Soul"). In 2007, the album was officially released for download. It would be Decker's last album/single release until the 2007 solo single "Just Dream".
Background
After the original split of T'Pau, Decker attempted a solo career. In 1993, she contributed a track to the soundtrack of the film Dirty Weekend, and the following year a small number of live performances followed. In 1995 she released the single "One Heart" - as the official anthem for the Halifax World Cup Rugby League Centenary '95. It peaked at #130 in the UK. She performed the song at Wembley Stadium during the opening and closing ceremonies. By 1997 though, Decker had taken the decision to build a 'new' T'Pau around her, and get back on the road after assembling a massive amount of new material. Although she considered continuing as a solo artist, it was advised that it would be easier if the band name was rekindled. The newly reformed band featured none of the original members aside from Decker. A brand new version of the band's original hit "Heart and Soul" was released as "Heart and Soul '97" (featuring the future Red album track "Make Love to Me"), and the band went onto Cilla Black's Surprise Surprise TV show to perform the song. However it was not a commercial success.
Red (audio drama)
Red is a Big Finish Productions audio drama based on the long-running British science fiction television series Doctor Who.
Plot
The citizens of the Needle are all chipped to prevent them from committing violence. When the Seventh Doctor and Mel arrive, they arouse interest as the only people able to cause harm…
Cast
External links
Reviews
Podcasts:
