RBBP8

Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.

Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Interactions

RBBP8 has been shown to interact with:

  • ATM,
  • BRCA1,
  • CTBP1,
  • LMO4,
  • RB1,
  • RBL1,
  • RBL2,{ and
  • SIAH1

    • References

    Further reading

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    This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/RBBP8

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