Activator

Activator may refer to:

Enzyme activator

Enzyme activators are molecules that bind to enzymes and increase their activity. They are the opposite of enzyme inhibitors. These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism. An example of an enzyme activator working in this way is fructose 2,6-bisphosphate, which activates phosphofructokinase 1 and increases the rate of glycolysis in response to the hormone insulin.

See also

References

Activator (genetics)

A transcriptional activator is a protein (transcription factor) that increases gene transcription of a gene or set of genes. Most activators are DNA-binding proteins that bind to enhancers or promoter-proximal elements.

Most activators function by binding sequence-specifically to a DNA site located in or near a promoter and making protein-protein interactions with the general transcription machinery (RNA polymerase and general transcription factors), thereby facilitating the binding of the general transcription machinery to the promoter. The DNA site bound by the activator is referred to as an "activator site." The part of the activator that makes protein-protein interactions with the general transcription machinery is referred to as an "activating region." The part of the general transcription machinery that makes protein-protein interactions with the activator is referred to as an "activation target."

Example

The catabolite activator protein (CAP; also known as cAMP receptor protein, CRP) activates transcription at the lac operon of the bacterium Escherichia coli.Cyclic adenosine monophosphate (cAMP) is produced during glucose starvation, binds to CAP, causes a conformational change that allows CAP to bind to a DNA site located adjacent to the lac promoter. CAP then makes a direct protein-protein interaction with RNA polymerase that recruits RNA polymerase to the lac promoter.

Rampage (2009 film)

Rampage is a 2009 mass murder thriller film directed by Uwe Boll and starring Brendan Fletcher, Michael Paré, Shaun Sipos and Lynda Boyd. Rampage received a theatrical release in Germany, though was released direct-to-video in the rest of the world. It was Boll's first film to gain mainly positive reviews. A sequel, titled Rampage: Capital Punishment, was released on August 19, 2014.

Plot

In the fictional town of Tenderville, Oregon, Bill Williamson, a 23-year-old man, is living with his parents and working a low-paid job as a mechanic, feeling bombarded with the problems of the world, by ubiquitous TV sets, radios, and the outspoken political views of 21-year-old Evan Drince, who seems to be his sole friend. Bill's parents ask him to move out and Bill leaves for work, stopping to get coffee along the way, and argues with the shop owner when he is unsatisfied with his coffee. At work, his boss interrupts him while Bill is working on a personal vehicle off the clock. The boss then condescendingly dismisses Bill's request for a raise.

Rampage (rapper)

Rampage (born August 1, 1974) is an American also called Rebel rapper who is a member of the Flipmode Squad. He was born as Roger McNair in Brooklyn, New York City to Katherine McNair and Roger Williams. He is a long-time collaborator with his cousin Busta Rhymes.

Music career

In 1992, Rampage landed his first recording deal with Dallas Austin on Rowdy / Arista Records and released the single Beware of the Rampsack. In 1994, he recorded Flava in Ya Ear (Remix) with Craig Mack, Notorious B.I.G., LL Cool J, and Busta Rhymes. In 1996, he recorded the Platinum Single "Woo Hah!! Got You All in Check" with Busta Rhymes for the platinum album The Coming.

One year later he landed his second recording deal with Elektra Records and released his Gold solo LP Scout's Honor... by Way of Blood which featured the top-40 hit "Take It to the Streets" and "Wild for the Night". In 1998 he released The Imperial with the Flipmode Squad, which gave them their first Source Award in 1999. Since then he has recorded with Busta Rhymes on numerous platinum albums and has featured on numerous projects including a remix of the multi-platinum single Fallin' by Alicia Keys.

List of Predacons

This is a list of the known Predacons from the Transformers fictional universe and toyline.

Generation 1 Predacons

Leaders

Predacons/Predaking

Stunticons/Menasor

Battlechargers

Pretenders

Triple Changers

Seekers

Duocons

Monsterbots

Terrorcons

Others