RALA

Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7. This protein is one of two isoforms of the Ral protein, the other being RalB, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.

Structure

The Ral isoforms share an 80% overall match in amino acid sequence and 100% match in their effector-binding region. The two isoforms mainly differ in the C-terminal hypervariable region, which contains multiple sites for post-translational modification, leading to diverging subcellular localization and biological function. For example, phosphorylation of Serine 194 on RalA by the kinase Aurora A results in the relocation of RalA to the inner mitochondrial membrane, where RalA helps carry out mitochondrial fission; whereas phosphorylation of Serine 198 on RalB by the kinase PKC results in the relocation of RalB to other internal membranes and activation of its tumorigenic function.

Çıralı

Çıralı is an agricultural village in southwest Turkey, in the Kemer district of Antalya Province. It is walking distance from the ancient ruins of Olympos and Chimaera permanent gas vents, located in the ancient Lycia region of Anatolia.

Çıralı is a very small rural village located just over an hour's drive southwest from Antalya. It has a 3.5 km secluded beach. The ancient ruins of Olympos are located at the far end of its coast. A long hike up the mountains is required to reach the flames of the Chimaera.

References

External links

List of Caribbean membranophones

This is a list of membranophones used in the Caribbean music area, including the islands of the Caribbean Sea, as well as the musics of Guyana, Suriname, French Guiana, Belize, Garifuna music, and Bermuda. It only includes membranophones that are indigenous to the local music area or are a vital and long-standing part of local culture. It does not include membranophones that are, for example, a part of Western style orchestras, nor does it include trap sets and other common membranophones used in popular music recordings of many genres across the world. Almost all membranophones are drums and percussion instruments.

The Hornbostel-Sachs number is given after each instrument.

References

List of RAL colors

Below is a list of RAL Classic colors from the RAL color standard.

RAL Classic

Yellow and beige

Orange

Red

Violett

Blue

Green

Grey

Brown

White and black

References