Notch

Notch may refer to:

See also

Neurogenic locus notch homolog protein 4

Neurogenic locus notch homolog 4 also known as notch 4 is a protein that in humans is encoded by the NOTCH4 gene located on chromosome 6.

Gene

An alternative splice variant of the NOTCH4 gene has been described, but its biological significance has not been determined.

Structure

The neurogenic locus notch homolog 4 protein is a member of the Notch family. Members of this type 1 transmembrane protein family share structural characteristics. These include an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain that consists of multiple, but different, domain types.

Function

Notch protein family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling pathway is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells

In Drosophilia, notch interacts with its cell-bound ligands (delta and serrate), and establishes an intercellular signaling pathway that then plays a key role in development. Homologues of the notch-ligands have also been identified in humans, but precise interactions between these ligands and the human notch homologues remain to be determined. The notch protein is cleaved in the trans-Golgi network, and then presented on the cell surface as a heterodimer. The protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal, and hepatic development.

Rain (Anthony Callea song)

"Rain" is the second song released by Australian Idol series two runner-up Anthony Callea, and features on his self-titled debut album Anthony Callea (2005). It was released as a double A-side set features the song plus his recording of Simon & Garfunkel's song "Bridge over Troubled Water", which he performed on Australian Idol.

The CD single for the song was released as a three-track standard version with the B-side "Don't Tell Me". It was also available for a short time as a limited edition collector's 2CD tri-gatefold set with a second B-side, "Wanna Be the One".

Track listing

Charts

"Rain" / "Bridge Over Troubled Water" debuted at #1 in Australia and remained at #1 for two weeks.

Ola Svensson version

In early 2006, Swedish singer Ola Svensson covered the song and released it as his debut single. Following his participation in Idol 2005, the single debuted at #1 on the Swedish singles chart and remained there for three consecutive weeks.

Rain (2006 film)

Rain is a 2006 film directed by Craig DiBona. The screenplay was written by Andrew Neiderman, based on the novel by V. C. Andrews. It premiered at the Palm Beach International Film Festival, although it did not receive further domestic distribution.

Plot

A talented young pianist named Rain (Brooklyn Sudano) is attacked by a vicious street gang which kills her sister. The gang sets out to find Rain while she hides in the care of a woman who is her natural grandmother. Rain was put up for adoption because the father of the baby was black and the mother was from a rich white family. Her adoptive mother (Khandi Alexander) sends her back because she is in danger for having witnessed her adoptive sister's murder.

Cast

Availability

The film is available to watch on such sites as Netflix to both rent and to watch on their online streaming option.

Rain (SWV song)

"Rain" is a 1998 single released by the group SWV. The musical backing track is based on Jaco Pastorius's "Portrait of Tracy." First heard in 1997 on the group's third album Release Some Tension, the song was released as a single the next year. It peaked at number 25 on the US Billboard Hot 100 singles chart and number 7 on the US Hot R&B Singles chart. Singer Tyrese appeared in the song's music video. He would later sing the hook on "Pullin' Me Back", a song by rapper Chingy, which sampled "Rain." Smooth Jazz musician Norman Brown covered the song on his 1999 album, Celebration. Toronto based producer duo Team Majestic Music, also sampled "Rain" for their song "Let It Fall."

Track listing

US Promo

US CD

UK CD