Ryanodine receptor 2
Ryanodine receptor 2 (RYR2) is a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2 gene. In the process of cardiac calcium-induced calcium release, RYR2 is the major mediator for sarcoplasmic release of stored calcium ions.
Structure
The channel is composed of RYR2 homotetramers and FK506-binding proteins found in a 1:4 stoichiometric ratio. Calcium channel function is affected by the specific type of FK506 isomer interacting with the RYR2 protein, due to binding differences and other factors.
Function
The RYR2 protein functions as the major component of a calcium channel located in the sarcoplasmic reticulum that supplies ions to the cardiac muscle during systole. To enable cardiac muscle contraction, calcium influx through voltage-gated L-type calcium channels in the plasma membrane allows calcium ions to bind to RYR2 located on the sarcoplasmic reticulum. This binding causes the release of calcium through RYR2 from the sarcoplasmic reticulum into the cytosol, where it binds to the C domain of troponin, which shifts tropomyosin and allows the myosin ATPase to bind to actin, enabling cardiac muscle contraction. RYR2 channels are associated with many cellular functions, including mitochondrial metabolism, gene expression and cell survival, in addition to their role in cardiomyocyte contraction.
Podcasts:
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by R24
Kill Me In My Sleep
by: R24I’ve kept this all locked up inside,
No longer can reside.
I’m sick of you, never return
Listen, I won’t be unheard.
You’re not trustworthy
Always lying to me.
I cannot trust you.
Or ANYONE.
I’ve waited this long, to tell you, I HOPE YOU BURN!
Can’t take this anymore. I want you buried deep.
Can’t take this anymore, if this goes on, if this goes on, if this goes on, just kill me in my sleep.
You can’t tell me the truth.
Don’t know you anymore.
Gotten out of hand
This was so unplanned.
Secrets Kept.
No friends left.
Go away.
Sit and decay. X2
I know you’ve been lying.
Not even trying. Not even trying.
I know you’ve been lying.
I can’t help you, I will not help you.
I wanted to tell you I HOPE YOU BURN!
Can’t take this anymore, I want you buried deep.
Can’t take this anymore. If this goes on, If this goes on, If this goes on, if this goes on, kill me in my sleep. X3
You’re on your own.
You’re all alone.
No one can trust you.
No one will help you.
I wanted to tell you I hope you burn,
Cant Take this anymore I want you buried deep.
I’ve kept this all locked up inside,
No longer can reside.
I’m sick of you, never return
Listen, I won’t be unheard.
You’re not trustworthy
Always lying to me.
I cannot trust you.
Or ANYONE.
I’ve waited this long, to tell you, I HOPE YOU BURN!
Can’t take this anymore. I want you buried deep.
Can’t take this anymore, if this goes on, if this goes on, if this goes on, just kill me in my sleep.
You can’t tell me the truth.
Don’t know you anymore.
Gotten out of hand
This was so unplanned.
Secrets Kept.
No friends left.
Go away.
Sit and decay. X2
I know you’ve been lying.
Not even trying. Not even trying.
I know you’ve been lying.
I can’t help you, I will not help you.
I wanted to tell you I HOPE YOU BURN!
Can’t take this anymore, I want you buried deep.
Can’t take this anymore. If this goes on, If this goes on, If this goes on, if this goes on, kill me in my sleep. X3
You’re on your own.
You’re all alone.
No one can trust you.
No one will help you.
I wanted to tell you I hope you burn,
Cant Take this anymore I want you buried deep.