Ryanodine receptor
Ryanodine receptors (RyRs) form a class of intracellular calcium channels in various forms of excitable animal tissue like muscles and neurons. There are three major isoforms of the ryanodine receptor, which are found in different tissues and participate in different signaling pathways involving calcium release from intracellular organelles. The RYR2 ryanodine receptor isoform is the major cellular mediator of calcium-induced calcium release (CICR) in animal cells.
Etymology
The ryanodine receptors are named after the plant alkaloid ryanodine, to which they show a high affinity:
Isoforms
There are multiple isoforms of ryanodine receptors:
RYR1
Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is a protein found primarily in skeletal muscle. In humans, it is encoded by the RYR1 gene.
Function
RYR1 functions as a calcium release channel in the sarcoplasmic reticulum, as well as a connection between the sarcoplasmic reticulum and the transverse tubule.
Clinical significance
Mutations in the RYR1 gene are associated with malignant hyperthermia susceptibility, central core disease, minicore myopathy with external ophthalmoplegia and samaritan myopathy, a benign congenital myopathy. Alternatively spliced transcripts encoding different isoforms have been demonstrated.Dantrolene may be the only known drug that is effective during cases of malignant hyperthermia.
Interactions
RYR1 has been shown to interact with:
See also
References
Further reading
External links
Podcasts:
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by R24
Kill Me In My Sleep
by: R24I’ve kept this all locked up inside,
No longer can reside.
I’m sick of you, never return
Listen, I won’t be unheard.
You’re not trustworthy
Always lying to me.
I cannot trust you.
Or ANYONE.
I’ve waited this long, to tell you, I HOPE YOU BURN!
Can’t take this anymore. I want you buried deep.
Can’t take this anymore, if this goes on, if this goes on, if this goes on, just kill me in my sleep.
You can’t tell me the truth.
Don’t know you anymore.
Gotten out of hand
This was so unplanned.
Secrets Kept.
No friends left.
Go away.
Sit and decay. X2
I know you’ve been lying.
Not even trying. Not even trying.
I know you’ve been lying.
I can’t help you, I will not help you.
I wanted to tell you I HOPE YOU BURN!
Can’t take this anymore, I want you buried deep.
Can’t take this anymore. If this goes on, If this goes on, If this goes on, if this goes on, kill me in my sleep. X3
You’re on your own.
You’re all alone.
No one can trust you.
No one will help you.
I wanted to tell you I hope you burn,
Cant Take this anymore I want you buried deep.
I’ve kept this all locked up inside,
No longer can reside.
I’m sick of you, never return
Listen, I won’t be unheard.
You’re not trustworthy
Always lying to me.
I cannot trust you.
Or ANYONE.
I’ve waited this long, to tell you, I HOPE YOU BURN!
Can’t take this anymore. I want you buried deep.
Can’t take this anymore, if this goes on, if this goes on, if this goes on, just kill me in my sleep.
You can’t tell me the truth.
Don’t know you anymore.
Gotten out of hand
This was so unplanned.
Secrets Kept.
No friends left.
Go away.
Sit and decay. X2
I know you’ve been lying.
Not even trying. Not even trying.
I know you’ve been lying.
I can’t help you, I will not help you.
I wanted to tell you I HOPE YOU BURN!
Can’t take this anymore, I want you buried deep.
Can’t take this anymore. If this goes on, If this goes on, If this goes on, if this goes on, kill me in my sleep. X3
You’re on your own.
You’re all alone.
No one can trust you.
No one will help you.
I wanted to tell you I hope you burn,
Cant Take this anymore I want you buried deep.