RTI-371
3β-(4-methylphenyl)-2β-[3-(4-chlorophenyl)isoxazol-5-yl]tropane (RTI-371) is a phenyltropane derived drug which acts as a potent and selective dopamine reuptake inhibitor in vitro, yet unusually for this class of compound, both RTI-371 and the closely related compound RTI-370 failed to produce locomotor stimulation in mice. In addition to this, in drug substitution tests RTI-370 weakly generalized to cocaine whereas RTI-371 did not generalize at all.
This phenomenon has also been observed for other dopamine reuptake inhibitors from other classes. It may be caused by lack of BBB penetration, or interactions at alternative receptor sites. Recently the second of these hypotheses was suggested for this compound when it was discovered that RTI-371 also acts as a positive allosteric modulator of the hCB1 human cannabinoid receptor.
See also
References
Podcasts:
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Ratt
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
-
by Red
Dead Reckoning
by: RattYou know you're livin' a lie when you just can't win
Pulling in first prize ain't gonna give you a break
You know I'm kickin' back, I had a broken wing
Me and my shadow are the next best thing
I need someone
You know it might take more than you give to me
Are you gun-shy, are you listening?
What we got here is dead reckoning
And take me in for the night in the right time zone
We'll do what you like, make a left turn home
I put out the light, you're turnin' way too red
No stop sign straight up ahead
You need so much
So much sympathy
That's more than I can say
You know it's not too late
Are you gun-shy, are you listening?
What we got here is dead reckoning
And if it feels good, we'll do it again
See your way clear, dead reckoning
Tell me why, tell me why
Are you listening?
Are you listening?
Are you listening?
Are you listening?
You mean so much
So much to me
That's more than I can say
You know it's not too late
Are you gun-shy, are you listening?
What we got here is dead reckoning
And if it feels good, we'll do it again
See your way clear, dead reckoning, yeah
What we got here is dead reckoning