(-)-2β-(1,2,4-Oxadiazol-5-methyl)-3β-phenyltropane

RTI-126 ((–)-2β-(1,2,4-oxadiazol-5-methyl)-3β-phenyltropane) is a phenyltropane derivative which acts as a potent monoamine reuptake inhibitor and stimulant drug. It is around 5 times more potent a stimulant than cocaine, but is relatively unselective. It binds to all three monoamine transporters, although still with some selectivity for the dopamine transporter. RTI-126 has a fast onset of effects and short duration of action, and its pharmacological profile in animals is among the closest to cocaine itself out of all the drugs in the RTI series. Its main application in scientific research has been in studies investigating the influence of pharmacokinetics on the abuse potential of stimulant drugs, with its rapid entry into the brain thought to be a key factor in producing its high propensity for development of dependence in animals.

The structurally related compound (–)-2β-(3-methyl-5-isoxazolyl)nortropane is a potent and selective agonist for nicotinic acetylcholine receptors, with twice the potency of nicotine.

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Dead Reckoning

by: Ratt

You know you're livin' a lie when you just can't win
Pulling in first prize ain't gonna give you a break
You know I'm kickin' back, I had a broken wing
Me and my shadow are the next best thing
I need someone
You know it might take more than you give to me
Are you gun-shy, are you listening?
What we got here is dead reckoning
And take me in for the night in the right time zone
We'll do what you like, make a left turn home
I put out the light, you're turnin' way too red
No stop sign straight up ahead
You need so much
So much sympathy
That's more than I can say
You know it's not too late
Are you gun-shy, are you listening?
What we got here is dead reckoning
And if it feels good, we'll do it again
See your way clear, dead reckoning
Tell me why, tell me why
Are you listening?
Are you listening?
Are you listening?
Are you listening?
You mean so much
So much to me
That's more than I can say
You know it's not too late
Are you gun-shy, are you listening?
What we got here is dead reckoning
And if it feels good, we'll do it again
See your way clear, dead reckoning, yeah
What we got here is dead reckoning




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