RTI-113
RTI-113 (2β-carbophenoxy-3β-(4-chlorophenyl)tropane) is a stimulant drug which acts as a potent and fully selective dopamine reuptake inhibitor (DRI). It has been suggested as a possible substitute drug for the treatment of cocaine addiction. "RTI-113 has properties that make it an ideal medication for cocaine abusers, such as an equivalent efficacy, a higher potency, and a longer duration of action as compared to cocaine." Replacing the methyl ester in RTI-31 with a phenyl ester makes the resultant RTI-113 fully DAT specific. RTI-113 is a particularly relevant phenyltropane cocaine analog that has been tested on squirrel monkeys. RTI-113 has also been tested against cocaine in self-administration studies for DAT occupancy by PET on awake rhesus monkeys. The efficacy of cocaine analogs to elicit self-administration is closely related to the rate at which they are administered. Slower onset of action analogs are less likely to function as positive reinforcers than analogues that have a faster rate of onset.
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Dead Reckoning
by: RattYou know you're livin' a lie when you just can't win
Pulling in first prize ain't gonna give you a break
You know I'm kickin' back, I had a broken wing
Me and my shadow are the next best thing
I need someone
You know it might take more than you give to me
Are you gun-shy, are you listening?
What we got here is dead reckoning
And take me in for the night in the right time zone
We'll do what you like, make a left turn home
I put out the light, you're turnin' way too red
No stop sign straight up ahead
You need so much
So much sympathy
That's more than I can say
You know it's not too late
Are you gun-shy, are you listening?
What we got here is dead reckoning
And if it feels good, we'll do it again
See your way clear, dead reckoning
Tell me why, tell me why
Are you listening?
Are you listening?
Are you listening?
Are you listening?
You mean so much
So much to me
That's more than I can say
You know it's not too late
Are you gun-shy, are you listening?
What we got here is dead reckoning
And if it feels good, we'll do it again
See your way clear, dead reckoning, yeah
What we got here is dead reckoning