Book of Ruth

The Book of Ruth (Hebrew: מגילת רות‎, Ashkenazi pronunciation: [məˈɡɪləs rus], Megilath Ruth, "the Scroll of Ruth", one of the Five Megillot) is a book of the Hebrew Bible/Old Testament. In the Jewish canon it is included in the third division, or the Writings (Ketuvim); in the Christian canon it is treated as a history book and placed between Judges and 1 Samuel. It is named after its central figure, Ruth the Moabitess, the great-grandmother of David.

The book tells of Ruth's accepting the God of the Israelites as her God and the Israelite people as her own. In Ruth 1:16 and 17 Ruth tells Naomi, her Israelite mother in law, "Where you go I will go, and where you stay I will stay. Your people will be my people and your God my God. Where you die I will die, and there I will be buried. May the Lord deal with me, be it ever so severely, if even death separates you and me." The book is held in esteem by Jews who fall under the category of Jews-by-choice, as is evidenced by the considerable presence of Boaz in rabbinic literature. The "Book of Ruth" also functions liturgically, as it is read during the Jewish holiday of Shavuot ("Weeks").

Thyroid hormone resistance

Thyroid hormone resistance (sometimes Refetoff syndrome) describes a rare syndrome in which the thyroid hormone levels are elevated but the thyroid stimulating hormone (TSH) level is not suppressed, or not completely suppressed as would be expected. The first report of the condition appeared in 1967. Essentially this is decreased end organ responsiveness to thyroid hormones. A new term "impaired sensitivity to thyroid hormone" has been suggested in March 2014 by Refetoff et al.

Regulation of thyroid hormone secretion

Hypothalamus secretes a hormone called thyrotropin releasing hormone (TRH) which in turn release thyroid stimulating hormone (TSH). TSH signals thyroid to secrete thyroid hormones thyroxine (T4) and triiodothyronine (T3). T4 gets converted to active T3 in peripheral tissues with the help of deiodinase enzymes. T3 negatively feedback on the pituitary and decreases TSH secretion.

Causes

Normal thyroid hormone function requires normal thyroid hormone transport across cell membrane, appropriate deiodination, thyroid hormone nuclear receptor, thyroid hormone response elements, co-activators, co-repressors, and normal histone acetylation. Any abnormalities in this chain can result in thyroid hormone resistance.

Brothers in Arms: Road to Hill 30

Brothers in Arms: Road to Hill 30 is a first-person shooter video game developed by Gearbox Software and published by Ubisoft for Xbox, Microsoft Windows, PlayStation 2 and OS X. It is the first game in the Brothers in Arms series. The game takes place during World War II and focuses on tactics. It was ported to the Wii in 2008, as part of the Brothers in Arms: Double Time compilation.

Brothers in Arms: Road to Hill 30 was also used to recreate scenarios in a 2005 History Channel special, also titled Brothers in Arms.

Gameplay

In most levels of Brothers in Arms, the player is in command of one or two separate 1-3 man teams, with the exception of several sections in which the player is not in command of any unit. There are two types of teams, which are automatically provided before each mission: