RPS6KA3

Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 gene.

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation.

Clinical significance

Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).

Interactions

RPS6KA3 has been shown to interact with CREB-binding protein,MAPK1 and PEA15.

References

Further reading

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