ROS1
Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene.
Function
This proto-oncogene, highly expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.
Interactions
ROS1 (gene) has been shown to interact with PTPN6.
Role in cancer
Gene rearrangements involving the ROS1 gene were first detected in glioblastoma tumors and cell lines. In 2007 a ROS1 rearrangement was identified in a cell line derived from a lung adenocarcinoma patient. Since that discovery, multiple studies have demonstrated an incidence of approximately 1% in lung cancers, demonstrated oncogenicity, and showed that inhibition of tumor cells bearing ROS1 gene fusions by crizotinib or other ROS1 tyrosine kinase inhibitors was effective in vitro. Clinical data supports the use of crizotinib in lung cancer patients with ROS1 gene fusions. Preclinical and clinical work suggests multiple potential mechanisms of drug resistance in ROS1+ lung cancer, including kinase domain mutations in ROS1 and bypass signaling via RAS and EGFR. Although the most preclinical and clinical studies of ROS1 gene fusions have been performed in lung cancer, ROS1 fusions have been detected in multiple other tumor histologies, including ovarian carcinoma, sarcoma, cholangiocarcinomas and others. Crizotinib or other ROS1 inhibitors may be effective in other tumor histologies beyond lung cancer as demonstrated by a patient with an inflammatory myofibroblastic tumor harboring a ROS1 fusion with a dramatic response to crizotinib.
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I've Been Up
by: Royce Da 5'9''We don't fear death, we fear for yourself
At the... 98 in hip hop...
Couple of dollars, couple of models, couple of bitches niggers under my
Belt
Down nigger, I'ma hold it too, if you hand shake my
Plan b is to complete plan a
... dissing my... I should get...
Why, why, why,
Would you listen... me
I brush my shoulders up, polish off
If you pray me...
I put them in the... paper
Rollercoaster career, focus been real for you
Because it's been weird for me
I feel like
They can take away the car,
They can take away the...
Run back at you at the game take a real...
I've been up, I've been down, I don't give a fuck, yeah
I've been up, I've been down, I don't give a fuck, yeah
I've been up, I've been down, I don't give a fuck, yeah
They can take away the car,
They can take away the...
Run back at you at the game take a real...
I just want mama to be happy
Is that too motherfucking much to ask
... bitch, can't get a jungle I hate liars
But I fuck with the lion is bitch
If you don't straighten your ass out right now
I will find you and iron you bitch
... dissing my... I should get...
Why, why, why,
Would you let love make you act like a faggot?
I'm fly
And you act like a maggot
Money comes money goes
I used to work funny clothes,
... my mama...
My real family all I care about...
I feel like
They can take away the car,
They can take away the...
Run back at you at the game take a real...
I've been up, I've been down, I don't give a fuck, yeah
I've been up, I've been down, I don't give a fuck, yeah
I've been up, I've been down, I don't give a fuck, yeah
They can take away the car,
They can take away the...
Run back at you at the game take a real...
And I watch my daddy hit my mama
Listen to my mama trying to calm...
When you gotta go visit your father
You be... as long as I'm getting... your mama will be sad
... when he got... he was having sick
Cause I was only 11 at the time
And he's been playing sober ever since
He gave me his advice, you got a huge advantage
Long as you know what's... in life
... people treat money like oxygen
When they got it did they get it for granted
But then lose in panic
... I look at him like superman
And y'all niggers ain't even close to me
So if he can fall, so can me
They can take away the car,
They can take away the...
Run back at you at the game take a real...
I've been up, I've been down, I don't give a fuck, yeah
I've been up, I've been down, I don't give a fuck, yeah
I've been up, I've been down, I don't give a fuck, yeah
They can take away the car,
They can take away the...
Latest News for: ros1
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