Rora

Rora may refer to:

  • Rora, a village administered by the city of Sighișoara, Mureş County, Romania
  • Rora, Aberdeenshire, a rural settlement in Aberdeenshire, Scotland
  • Rora, a diminutive of the Russian feminine first name Avrora (a form of Aurora)
  • Rorà, a municipality in Piedmont, Italy
  • Røra, a village in Nord-Trøndelag County, Norway
  • RORA, RAR-related orphan receptor alpha, a gene / protein
  • RAR-related orphan receptor alpha

    RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is encoded by the RORA gene. RORα participates in the transcriptional regulation of some genes involved in circadian rhythm.

    Discovery

    The first three human isoforms of RORα were initially cloned and characterized as nuclear receptors in 1994 by Giguère and colleagues, when their structure and function were first studied.

    In the early 2000s, various studies demonstrated that RORα displays rhythmic patterns of expression in a circadian cycle in the liver, kidney, retina, and lung. Of interest, it was around this time that RORα abundance was found to be circadian in the mammalian suprachiasmatic nucleus. RORα is necessary for normal circadian rhythms in mice, demonstrating its importance in chronobiology.

    Structure

    The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. In humans, 4 isoforms of RORα have been identified, which are generated via alternative splicing and promoter usage, and exhibit differential tissue-specific expression. The protein structure of RORα consists of four canonical functional groups: an N-terminal (A/B) domain, a DNA-binding domain containing two zinc fingers, a hinge domain, and a C-terminal ligand-binding domain. Within the ROR family, the DNA-binding domain is highly conserved, and the ligand-binding domain is only moderately conserved. Different isoforms of RORα have different binding specificities and strengths of transcriptional activity.

    Rorà

    Rorà is a comune (municipality) in the Province of Turin in the Italian region Piedmont, located about 50 km southwest of Turin.

    It was the scene of several campaigns against the Waldensians and is historically linked to Joshua Janavel. Nearby Torre Pellice is the center of the Waldensian church.

    Rorà borders the following municipalities: Villar Pellice, Torre Pellice, Luserna San Giovanni, and Bagnolo Piemonte.

  • Village of Rorà, abt. 1895

  • Village of Rorà, abt. 1895

  • Scene of Jeneval's victory above Rorà.

  • Scene of Jeneval's victory above Rorà.

  • Scene of the victory above Rorà.

  • Scene of the victory above Rorà.

  • Road on the way to Rorà, abt. 1895

  • Road on the way to Rorà, abt. 1895

  • Map of the Waldensian Valley

  • Map of the Waldensian Valley

    References

  • Demographic data from Istat
  • "A short history of the Waldensian church in the valleys of Piedmont, from the earliest period to the present time, by Jane Louisa Willyams". Nisbet. 1855. Retrieved January 2016.
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