ROR2
Tyrosine-protein kinase transmembrane receptor ROR2 also known as neurotrophic tyrosine kinase, receptor-related 2, is a protein that in humans is encoded by the ROR2 gene located on position 9 of the long arm of chromosome 9. This protein is responsible for aspects of bone and cartilage growth. It is involved in Robinow syndrome and autosomal dominant brachydactyly type B. ROR2 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.
Function
The protein encoded by this gene is a receptor tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development.
Clinical significance
Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
Podcasts:
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by R24
Kill Me In My Sleep
by: R24I’ve kept this all locked up inside,
No longer can reside.
I’m sick of you, never return
Listen, I won’t be unheard.
You’re not trustworthy
Always lying to me.
I cannot trust you.
Or ANYONE.
I’ve waited this long, to tell you, I HOPE YOU BURN!
Can’t take this anymore. I want you buried deep.
Can’t take this anymore, if this goes on, if this goes on, if this goes on, just kill me in my sleep.
You can’t tell me the truth.
Don’t know you anymore.
Gotten out of hand
This was so unplanned.
Secrets Kept.
No friends left.
Go away.
Sit and decay. X2
I know you’ve been lying.
Not even trying. Not even trying.
I know you’ve been lying.
I can’t help you, I will not help you.
I wanted to tell you I HOPE YOU BURN!
Can’t take this anymore, I want you buried deep.
Can’t take this anymore. If this goes on, If this goes on, If this goes on, if this goes on, kill me in my sleep. X3
You’re on your own.
You’re all alone.
No one can trust you.
No one will help you.
I wanted to tell you I hope you burn,
Cant Take this anymore I want you buried deep.
I’ve kept this all locked up inside,
No longer can reside.
I’m sick of you, never return
Listen, I won’t be unheard.
You’re not trustworthy
Always lying to me.
I cannot trust you.
Or ANYONE.
I’ve waited this long, to tell you, I HOPE YOU BURN!
Can’t take this anymore. I want you buried deep.
Can’t take this anymore, if this goes on, if this goes on, if this goes on, just kill me in my sleep.
You can’t tell me the truth.
Don’t know you anymore.
Gotten out of hand
This was so unplanned.
Secrets Kept.
No friends left.
Go away.
Sit and decay. X2
I know you’ve been lying.
Not even trying. Not even trying.
I know you’ve been lying.
I can’t help you, I will not help you.
I wanted to tell you I HOPE YOU BURN!
Can’t take this anymore, I want you buried deep.
Can’t take this anymore. If this goes on, If this goes on, If this goes on, if this goes on, kill me in my sleep. X3
You’re on your own.
You’re all alone.
No one can trust you.
No one will help you.
I wanted to tell you I hope you burn,
Cant Take this anymore I want you buried deep.