RO5166017
RO-5166017 is a drug developed by Hoffmann-La Roche which acts as a potent and selective agonist for the trace amine-associated receptor 1, with no significant activity at other targets. This is important for the study of the TAAR1 receptor, as while numerous other compounds are known which act as TAAR1 agonists, such as methamphetamine, MDMA and 3-iodothyronamine, all previously known TAAR1 agonists are either weak and rapidly metabolized (endogenous ligands), or have strong pharmacological activity at other targets (amphetamines, thyronamines), making it very difficult to assess which effects are due to TAAR1 activation. The discovery of RO-5166017 allows purely TAAR1 mediated effects to be studied, and in animal studies it was shown to prevent stress-induced hyperthermia and block dopamine-dependent hyperlocomotion, as well as blocking the hyperactivity which would normally be induced by an NMDA antagonist.
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Skorn
by: RaDear John, I'm sorry I can't do this anymore
You're not the man I fell in love with
And I have to move on with my life, goodbye
Goodbye, goodbye, goodbye cool
You were the one who'd never leave
Beautiful eyes, you seemed so free
Touching your face I felt complete
Holding your hand my heart would weep
So everything that came out of your mouth was full of lies
You looked me right dead in the eyes
You'd call your girlfriends and tell them that I abused your trust
You did your best to demonize
You were the one who'd never leave
Beautiful eyes, you seemed so free
Touching your face I felt complete
Holding your hand my heart would weep
You were the one who raped my soul
Beautiful lies, you stole my hope
Touching your ass, I scratch the skin
Holding your neck, I tie the rope
(Pulling it tight)
You were the one who'd never leave
Beautiful eyes, you seemed so free
Touching your face I felt complete
Holding your hand my heart would weep
You were the one, the one for me
Now that you're gone it's hard to see
So much of me has gone away
There's no need to stay another day
But someone's got to pay
But someone's got to pay
But someone's got to pay
But someone's got to pay
But someone's got to pay
But someone's got to pay
But someone's got to pay