Rnf41

Ring finger protein 41

PDB rendering based on 2fzp.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2FZP, 2GWF

Identifiers

Symbols

RNF41; FLRF; NRDP1

External IDs

MGI: 1914838 HomoloGene: 4226 GeneCards: RNF41 Gene

EC number

6.3.2.-

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • ubiquitin-protein ligase activity • protein binding • zinc ion binding • ligase activity • acid-amino acid ligase activity • protein tag • metal ion binding
Cellular component	• cytosol
Biological process	• protein polyubiquitination • apoptotic process • induction of apoptosis • protein ubiquitination • regulation of reactive oxygen species metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
56.6 – 56.62 Mb

Chr 10:
127.85 – 127.88 Mb

PubMed search

[1]

[2]

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.^[1]

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.^[1]

1 Interactions
2 See also
3 References
4 Further reading
5 External links

Interactions [link]

RNF41 has been shown to interact with USP8.^[2]

References [link]

^ ^a ^b "Entrez Gene: RNF41 ring finger protein 41". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10193.
^ Wu, Xiuli; Yen Lily, Irwin Lisa, Sweeney Colleen, Carraway Kermit L (Sep. 2004). "Stabilization of the E3 Ubiquitin Ligase Nrdp1 by the Deubiquitinating Enzyme USP8". Mol. Cell. Biol. (United States) 24 (17): 7748–57. DOI:10.1128/MCB.24.17.7748-7757.2004. ISSN 0270-7306. PMC 506982. PMID 15314180. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=506982.

Further reading [link]

Cao Z, Wu X, Yen L et al. (2007). "Neuregulin-Induced ErbB3 Downregulation Is Mediated by a Protein Stability Cascade Involving the E3 Ubiquitin Ligase Nrdp1". Mol. Cell. Biol. 27 (6): 2180–8. DOI:10.1128/MCB.01245-06. PMC 1820496. PMID 17210635. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1820496.
Avvakumov GV, Walker JR, Xue S et al. (2007). "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)". J. Biol. Chem. 281 (49): 38061–70. DOI:10.1074/jbc.M606704200. PMID 17035239.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wu X, Yen L, Irwin L et al. (2004). "Stabilization of the E3 Ubiquitin Ligase Nrdp1 by the Deubiquitinating Enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. DOI:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=506982.
Qiu XB, Markant SL, Yuan J, Goldberg AL (2005). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis". EMBO J. 23 (4): 800–10. DOI:10.1038/sj.emboj.7600075. PMC 380992. PMID 14765125. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=380992.
Brajenovic M, Joberty G, Küster B et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. DOI:10.1074/jbc.M312171200. PMID 14676191.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Qiu XB, Goldberg AL (2003). "Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14843–8. DOI:10.1073/pnas.232580999. PMC 137506. PMID 12411582. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137506.
Diamonti AJ, Guy PM, Ivanof C et al. (2002). "An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2866–71. DOI:10.1073/pnas.052709799. PMC 122439. PMID 11867753. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122439.
Abdullah JM, Li X, Nachtman RG, Jurecic R (2001). "FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors". Blood Cells Mol. Dis. 27 (1): 320–33. DOI:10.1006/bcmd.2001.0390. PMID 11358394.
Yu W, Andersson B, Worley KC et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. DOI:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146.
Andersson B, Wentland MA, Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. DOI:10.1006/abio.1996.0138. PMID 8619474.