Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.[1][2][3]
Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.[supplied by OMIM][3]
Interactions [link]
RGS6 has been shown to interact with STMN2[4] and DMAP1.[2]
References [link]
- ^ Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (Apr 1999). "The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3". J Hum Genet 44 (2): 138–40. DOI:10.1007/s100380050129. PMID 10083744.
- ^ a b Liu Z, Fisher RA (Mar 2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity". J Biol Chem 279 (14): 14120–8. DOI:10.1074/jbc.M309547200. PMID 14734556.
- ^ a b "Entrez Gene: RGS6 regulator of G-protein signalling 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9628.
- ^ Liu, Zhengyu; Chatterjee Tapan K, Fisher Rory A (Oct. 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. (United States) 277 (40): 37832–9. DOI:10.1074/jbc.M205908200. ISSN 0021-9258. PMID 12140291.
Further reading [link]
- Sherrington R, Rogaev EI, Liang Y, et al. (1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature 375 (6534): 754–60. DOI:10.1038/375754a0. PMID 7596406.
- Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. DOI:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26909.
- Posner BA, Gilman AG, Harris BA (1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. DOI:10.1074/jbc.274.43.31087. PMID 10521509.
- Liu Z, Chatterjee TK, Fisher RA (2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. 277 (40): 37832–9. DOI:10.1074/jbc.M205908200. PMID 12140291.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Chatterjee TK, Fisher RA (2003). "Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins". J. Biol. Chem. 278 (32): 30272–82. DOI:10.1074/jbc.M212688200. PMID 12761220.
- Chatterjee TK, Liu Z, Fisher RA (2003). "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants". J. Biol. Chem. 278 (32): 30261–71. DOI:10.1074/jbc.M212687200. PMID 12761221.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
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