Repulsive guidance molecule A also known as RGMa is a protein that in humans is encoded by the RGMA gene.
RGMa is a repulsive guidance molecule for retinal axons. Furthermore neogenin functions as a receptor for RGM. Neogenin overexpression and RGM downexpression in the developing embryonic neural tube induces apoptosis. The apoptotic activity of neogenin in the neural tube is associated with cleavage of its cytoplasmic domain by caspases.
RGMA belongs to a family of repulsive guidance molecules that are (glycosylphosphatidylinositol)-linked cell-membrane-associated proteins. The three proteins, RGMa (this protein), RGMb and RGMc are 40-50% identical to each other, and share similarities in predicted protein domains and overall structure. All three RGM proteins appear capable of binding selected BMPs (bone morphogenetic proteins).
RGMs may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion. RGMs can coordinate Smad-dependent and Smad-independent signalling of BMPs in prostate cancer and breast cancer cells.
(Keep you goin' when i'm flowin' smooth enough)
Yes Yes Y'all, i still fiend by any means a flow
and i go through extremes don't intervene
my adventures show like a three dimensional screen
coz i mention many things and i'm presenting many scenes
i guess i'm telegraphic, motions energentic
better tell 'em forget it, coz i'm telekinetic
ideas is blowin', mics is blowin
from what i'm showin, see it , i keep it goin' when i'm flowin
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through
Poetical pages cause panic, freestyles is frantic
thoughts is organic, flow is aerodynamic
mic is volcanic, rhymes spread across the planet
I send out the scribe now the vibes gigantic
Now, I'm internationally known, mental capacitys blown
I hope your microphones accident prone, raw footage is shown
but only showin' scenes of my own
puttin' your periphereal vision in a zone
but not the twilight, from the insight that i write
and recite, in my mic , will be bright , coz i like
the night glowin', its out of sight what i'm showin
rappers are knowin', i keep it goin' when i'm flowin
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through
When i'm flowin', theoritically speakin' like a drummer
I take you through the streets, to the park in the summer
or illustrate, a time and place you've never been
and make you focus on the future after seein' the beginning
and my style wilds like Miles on the trumpet
volume dial is kinda low , need to pump it
up another notch, turn the dial till it stops
more watts you got, more things to watch
third eye's wide open, you focus on a theory
keep scopin' till you hear me, words are spoken clearly
its no smoke screens on the scenes that i'm showin
man i keep it goin', damn i keep it flowin
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through
Accurate tactics make 'em clap to this
when i move the crowd, my rhythm still dont miss
breeze through melodies coz its been a long time
my lyrics is fury and rappers hate to hear me rhyme
every antidote that i quote, is no joke
nobodys smilin' in the ghetto from the notes i wrote
my high techniques wreck and disrepect beats
have you followin' the leader up and down the streets
so kick along, as i rip a song with pull
as the rhyme goes on i get paid in full
its Rakim, indicating rhymes for the showin
check it out y'all, i keep it goin' when i'm flowin
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through
I get visual, scenes of the lyrical individuals critical
non kids can do, i'm comin' through