UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.[1]
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.[2]
RAD23A has been shown to interact with PSMD4,[3][4] Sequestosome 1[5] and Ataxin 3.[6]
- ^ van der Spek PJ, Smit EM, Beverloo HB, Sugasawa K, Masutani C, Hanaoka F, Hoeijmakers JH, Hagemeijer A (March 1995). "Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23". Genomics 23 (3): 651–658. DOI:10.1006/geno.1994.1554. PMID 7851894.
- ^ "Entrez Gene: RAD23A RAD23 homolog A (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5886.
- ^ Hiyama, H; Yokoi M, Masutani C, Sugasawa K, Maekawa T, Tanaka K, Hoeijmakers J H, Hanaoka F (September 1999). "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome". J. Biol. Chem. (UNITED STATES) 274 (39): 28019–28025. DOI:10.1074/jbc.274.39.28019. ISSN 0021-9258. PMID 10488153.
- ^ Mueller, Thomas D; Feigon Juli (September 2003). "Structural determinants for the binding of ubiquitin-like domains to the proteasome". EMBO J. (England) 22 (18): 4634–4645. DOI:10.1093/emboj/cdg467. ISSN 0261-4189. PMC 212733. PMID 12970176. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=212733.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–1178. DOI:10.1038/nature04209. PMID 16189514.
- ^ Wang, G; Sawai N, Kotliarova S, Kanazawa I, Nukina N (July 2000). "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B". Hum. Mol. Genet. (ENGLAND) 9 (12): 1795–1803. DOI:10.1093/hmg/9.12.1795. ISSN 0964-6906. PMID 10915768.
- Eichbaum QG, Beatty DW, Parker MI (1994). "Identification of cardiac autoantigens in human heart cDNA libraries using acute rheumatic fever sera". J. Autoimmun. 7 (2): 243–261. DOI:10.1006/jaut.1994.1019. PMID 8037842.
- Masutani C, Sugasawa K, Yanagisawa J et al. (1994). "Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23". EMBO J. 13 (8): 1831–43. PMC 395023. PMID 8168482. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395023.
- van der Spek PJ (1996). "XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes". Nucleic Acids Res. 24 (13): 2551–2559. DOI:10.1093/nar/24.13.2551. PMC 145966. PMID 8692695. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=145966.
- van der Spek PJ (1996). "Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23". Genomics 31 (1): 20–27. DOI:10.1006/geno.1996.0004. PMID 8808275.
- Li L, Lu X, Peterson C, Legerski R (1997). "XPC interacts with both HHR23B and HHR23A in vivo". Mutat. Res. 383 (3): 197–203. PMID 9164480.
- Withers-Ward ES, Jowett JB, Stewart SA et al. (1997). "Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair". J. Virol. 71 (12): 9732–42. PMC 230283. PMID 9371639. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230283.
- Schauber C, Chen L, Tongaonkar P et al. (1998). "Rad23 links DNA repair to the ubiquitin/proteasome pathway". Nature 391 (6668): 715–718. DOI:10.1038/35661. PMID 9490418.
- Gragerov A, Kino T, Ilyina-Gragerova G et al. (1998). "HHR23A, the human homologue of the yeast repair protein RAD23, interacts specifically with Vpr protein and prevents cell cycle arrest but not the transcriptional effects of Vpr". Virology 245 (2): 323–330. DOI:10.1006/viro.1998.9138. PMID 9636371.
- Dieckmann T, Withers-Ward ES, Jarosinski MA et al. (1998). "Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr". Nat. Struct. Biol. 5 (12): 1042–1047. DOI:10.1038/4220. PMID 9846873.
- Kumar S, Talis AL, Howley PM (1999). "Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination". J. Biol. Chem. 274 (26): 18785–18792. DOI:10.1074/jbc.274.26.18785. PMID 10373495.
- Hiyama H, Yokoi M, Masutani C et al. (1999). "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome". J. Biol. Chem. 274 (39): 28019–28025. DOI:10.1074/jbc.274.39.28019. PMID 10488153.
- Miao F, Bouziane M, Dammann R et al. (2000). "3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins". J. Biol. Chem. 275 (37): 28433–28438. DOI:10.1074/jbc.M001064200. PMID 10854423.
- Wang G, Sawai N, Kotliarova S et al. (2000). "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B". Hum. Mol. Genet. 9 (12): 1795–1803. DOI:10.1093/hmg/9.12.1795. PMID 10915768.
- Withers-Ward ES, Mueller TD, Chen IS, Feigon J (2001). "Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr". Biochemistry 39 (46): 14103–14112. DOI:10.1021/bi0017071. PMID 11087358.
- Zhu Q, Wani G, Wani MA, Wani AA (2001). "Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53". Cancer Res. 61 (1): 64–70. PMID 11196199.
- Mansky LM, Preveral S, Le Rouzic E et al. (2001). "Interaction of human immunodeficiency virus type 1 Vpr with the HHR23A DNA repair protein does not correlate with multiple biological functions of Vpr". Virology 282 (1): 176–185. DOI:10.1006/viro.2000.0791. PMID 11259200.
- Gaynor EM, Chen IS (2001). "Analysis of apoptosis induced by HIV-1 Vpr and examination of the possible role of the hHR23A protein". Exp. Cell Res. 267 (2): 243–257. DOI:10.1006/excr.2001.5247. PMID 11426943.
- Chen L, Shinde U, Ortolan TG, Madura K (2002). "Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly". EMBO Rep. 2 (10): 933–938. DOI:10.1093/embo-reports/kve203. PMC 1084081. PMID 11571271. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1084081.
- Elder RT, Song XQ, Chen M et al. (2002). "Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination". Nucleic Acids Res. 30 (2): 581–591. DOI:10.1093/nar/30.2.581. PMC 99819. PMID 11788722. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99819.
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PDB gallery
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1dv0: Refined NMR solution structure of the C-terminal UBA domain of the human homologue of RAD23A (HHR23A)
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1f4i: SOLUTION STRUCTURE OF THE HHR23A UBA(2) MUTANT P333E, DEFICIENT IN BINDING THE HIV-1 ACCESSORY PROTEIN VPR
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1ify: Solution Structure of the Internal UBA Domain of HHR23A
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1oqy: Structure of the DNA repair protein hHR23a
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1p98: High-resolution NMR structure of the Ubl-domain of HHR23A
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1p9d: High-resolution structure of the complex of HHR23A ubiquitin-like domain and the C-terminal ubiquitin-interacting motif of proteasome subunit S5a
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1qze: HHR23a protein structure based on residual dipolar coupling data
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1tp4: Solution structure of the XPC binding domain of hHR23A protein
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| Excision repair |
Base excision repair/ AP site ( DNA glycosylase, Uracil-DNA glycosylase, Poly ADP ribose polymerase) • Nucleotide excision repair/ ERCC ( XPA, XPB, XPC, XPD/ERCC2, XPE/DDB1, XPF/DDB1, XPG/ERCC5, ERCC1, RPA, RAD23A, RAD23B, Excinuclease)
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| Other forms of repair |
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| Other/ungrouped proteins |
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| Regulation |
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| Other/ungrouped |
8-Oxoguanine • Adaptive response • Meiotic recombination checkpoint • RecF pathway
DNA helicase: BLM · WRN
FANC proteins: core protein complex ( FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM), FANCD1, FANCD2, FANCI, FANCJ, FANCN
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see also DNA repair-deficiency disorder
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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