Pathology

Pathology (from the Ancient Greek roots of pathos (πάθος), meaning "experience" or "suffering", and -logia (-λογία), "study of") is a significant component of the causal study of disease and a major field in modern medicine and diagnosis.

The term pathology itself may be used broadly to refer to the study of disease in general, incorporating a wide range of bioscience research fields and medical practices (including plant pathology and veterinary pathology), or more narrowly to describe work within the contemporary medical field of "general pathology," which includes a number of distinct but inter-related medical specialties which diagnose disease mostly through the analysis of tissue, cell, and body fluid samples. Used as a count noun, "a pathology" (plural, "pathologies") can also refer to the predicted or actual progression of particular diseases (as in the statement "the many different forms of cancer have diverse pathologies"), and the affix path is sometimes used to indicate a state of disease in cases of both physical ailment (as in cardiomyopathy) and psychological conditions (such as psychopathy). Similarly, a pathological condition is one caused by disease, rather than occurring physiologically. A physician practicing pathology is called a pathologist.

Pathology (band)

Pathology is an American death metal band from San Diego, California, formed in 2006 by drummer Dave Astor (previously with The Locust and Cattle Decapitation). The band were signed to Victory Records for an over three-year period, but now are currently signed to Sevared Records, an independent New York-based death metal label.

History

In 2006 the band released Surgically Hacked (Amputated Vein Records) which was followed by a full-length debut Incisions of Perverse Debauchery (Grindhead Records) and then Age of Onset (Comatose Records, 2009), the album which led to a contract with Victory Records where the acclaimed Legacy of the Ancients was released on July 6, 2010.

The band began extensive touring (with Nile, with Immolation, Vader, Obituary and Deicide, and with Deströyer 666, among others) but in November a horrible van accident derailed the band from continuing. At that point, the original vocalist Matti Way was replaced by Jonathan Huber (formerly of I Declare War). Guitarist Tim Tiszczenko, who at one point departed to be replaced by Kevin Schwartz, returned to form a guitar tandem with the latter. In May 2011, it was announced that Pathology would enter Lambesis Studios that summer with producer Daniel Castleman to begin working on a new full-length expected in Autumn. On August 30, the band was to start the US tour supporting Grave and Blood Red Throne.

Pathology (film)

Pathology is a 2008 medical thriller directed by Marc Schölermann and written by Mark Neveldine and Brian Taylor. The cast was announced on April 4, 2007 and filming started in May 2007. The film premiered April 11, 2008 in the United Kingdom and opened in limited release in the United States on April 18, 2008.

Plot

The intro shows a camera recording faces of corpses, with their mouths being moved by medical students.

Med school student Teddy Grey (Milo Ventimiglia) graduates top of his class from Harvard and joins one of the nation’s most prestigious pathology programs. There, a rivalry develops between a group of interns and Teddy. They invite him into their group, which entertains itself with a secret after-hours game at the morgue of who can commit the perfect undetectable murder. Eventually the group's leader, Jake Gallo, realizes that Teddy is sleeping with his girlfriend, Dr. Juliette Bath. When Teddy catches several members of the group in lies, he realizes that what initially seemed like vigilante killings are, in actuality, just innocent people murdered for sport.

RAB27

Rab27 is a member of the Rab subfamily of GTPases. Rab27 is post translationally modified by the addition of two geranylgeranyl groups on the two C-terminal cysteines.

Pathology

Mutations that prevent the expression of Rab27 ('knock out' mutations) cause the hypopigmentation and immunodefficiency disorder known as type II Griscelli syndrome, while a decrease in Rab27 prenylation is thought to be involved in choroideremia.

The symptoms of type II Griscelli syndrome have shown that Rab27 is involved in melanosome transport in melanocytes and in cytotoxic killing activity in cytotoxic T lymphoblasts. In melanocytes Rab27 binds the melanosome. The melanosome is transported along the microtubule. Rab27 then recruits Slac2A and myosin Va, these enzymes are essential for the transfer of the melanosomes from the microtubules to actin filaments. The melanosomes can now continue on their path towards the cell periphery. If either Rab27, Slac2A or myosin Va are absent then the melansomes remain in the perinuclear region of the cell. This disruption in pigmentation results in the hypopigmentation seen in the silvery hair colour of patients with Griscelli syndrome.