Silodosin
Silodosin (trade names Rapaflo (USA), Silodyx (Europe and South Africa), Rapilif (India), Silodal (India), Urief (Japan), Urorec (Russia)) is a medication for the symptomatic treatment of benign prostatic hyperplasia. It acts as an α1-adrenoceptor antagonist with high uroselectivity (selectivity for the prostate).
History
Silodosin received its first marketing approval in Japan in May 2006 under the tradename Urief, which is jointly marketed by Kissei Pharmaceutical Co., Ltd. and Daiichi Sankyo Pharmaceutical Co., Ltd.
Kissei licensed the US, Canadian, and Mexican rights for silodosin to Watson Pharmaceuticals, Inc. in 2004.
FDA approved silodosin on October 9, 2008. Silodosin is marketed under the trade names Rapaflo in the US and Silodyx in Europe. and Rapilif in India (Ipca Urosciences)
Pharmacology
Since silodosin has high affinity for the α1A adrenergic receptor, it causes practically no orthostatic hypotension (in contrast to other α1 blockers). On the other side, the high selectivity seems to be the cause of silodosin's typical side effect of retrograde ejaculation.
KMD
KMD (Kausing Much Damage, or A positive Kause in a Much Damaged society) was a hip hop trio active in the early 1990s. The group is best known for launching the career of rapper and producer Zev Love X, who later became MF DOOM. Zev Love X and his younger brother DJ Subroc formed the core of KMD. The group's original third member, Rodan, left before the group signed with Elektra Records; he was replaced with Onyx the Birthstone Kid.
History
Zev Love X, DJ Subroc and Rodan formed KMD in Long Beach, New York, in 1988. The three were Black Muslims active in the Allah Ansaar community. KMD starts as a graffiti crew, who also practises breakdance.
Onyx the Birthstone Kid soon replaced Rodan, who left the group in order to finish high school. MC Serch, a native of nearby Far Rockaway, met the group at community functions and recruited them for a guest spot on "The Gas Face," a single off 3rd Bass' The Cactus Album. The guest appearance caught the attention of A&R executive Dante Ross, who signed KMD to Elektra Records.
KMD (disambiguation)
KMD may refer to:
Podcasts:
