Pueblo Revolt
The Pueblo Revolt of 1680 — also known as Popé's Rebellion — was an uprising of most of the indigenous Pueblo people against the Spanish colonizers in the province of Santa Fe de Nuevo México, present day New Mexico. The Pueblo Revolt killed 400 Spanish and drove the remaining 2,000 settlers out of the province. Twelve years later the Spanish returned and were able to reoccupy New Mexico with little opposition.
Background
For more than 100 years beginning in 1540, the Pueblo Indians of present-day New Mexico were subjected to seven successive waves of soldiers, missionaries, and settlers. [Citation needed.] These encounters, referred to as the Entradas, were characterized by violent confrontations between Spanish colonists and Pueblo peoples. The Tiguex War, fought in the winter of 1540-41 by the expedition of Francisco Vásquez de Coronado against the twelve or thirteen pueblos of Tiwa Indians, was particularly destructive to Pueblo and Spanish relations.
In 1598 Juan de Oñate led 129 soldiers and 10 Franciscan Catholic priests plus a large number of women, children, servants, slaves, and livestock into the Rio Grande valley of New Mexico. There were at the time approximately 40,000 Pueblo Indians inhabiting the region. Oñate put down a revolt at Acoma Pueblo by killing and enslaving hundreds of the Indians and sentencing 24 men to have their right foot cut off. The Acoma Massacre would instill fear of the Spanish in the region for years to come, though Franciscan missionaries were assigned to several of the Pueblo towns to Christianize the natives.