Prostaglandin DP2 receptor
Prostaglandin D2 receptor 2 (DP2) is a human protein encoded by the PTGDR2 gene. DP2 has also been designated as CD294 (cluster of differentiation 294).
Function
G protein-coupled receptors (GPCRs), such as DP2, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM]
DP2 has recently been found when activated by elevated level of prostaglandin D2 (PGD2), it could inhibit hair growth. This suggests the DP2 pathway as a potential target for bald treatment. A particularly promising compound for blocking the DP2 pathway is a compound known as TM30089, which exhibits a "functional insurmountability" of PGD2 expression.
Ligands
Agonists
Antagonists
Prostaglandin DP1 receptor
Prostaglandin D2 receptor 1 (DP1) is a G protein-coupled receptor, encoded by the PTGDR1 gene, for prostaglandin D2 (PGD2).
Mechanism
DP1 is a G protein-coupled receptor (GPCR). Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+.
Function
Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2, functions as a mast cell-derived mediator to trigger asthmatic responses. It also causes vasodilation
Ligands
See also
References
External links
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Prostaglandin D2 receptor
The prostaglandin D2 (PGD2) receptors are G protein-coupled receptors that bind and are activated by prostaglandin D2. They include the following proteins:
