Ptc1 is a type Two C phosphatase involved in the mating decision of yeast. Ptc1 competes with Fus3 for control of the 4 phosphorylation sites on the scaffold protein Ste5. Presence of the mating pheromone α-factor causes Ptc1 to be recruited to Ste5. This recruitment takes place via a 4 amino acid motif in the Ste5 phosphosites.
Ptc1 is also involved in regulating the osmotic stress of yeast, especially via inactivation of Hog1, a member of the MAPK pathway. This inactivation occurred as a result of dephosphorylation of the phosphotheronine but not the phosphotyrosine residue in the phosphorylation lip of Hog1.
It can be localized to the cytoplasm and nucleus.
Ptc1 is involved in the following biological processes:
The Players Tour Championship is a series of snooker tournaments comprising six minor-ranking events played in Europe, and an Asian leg comprising three minor-ranking events. The series concludes with a Grand Final, where qualification is based on performance in the other PTC events, and carries the status of a full ranking tournament. Each regular event lasts for at least three days, with qualifying days for amateurs should the event be oversubscribed. Each event costs £100 to enter, and Main Tour players can gain ranking points in the events.
The inaugural series ran from late June, with six events at the World Snooker Academy in Sheffield, one in Gloucester and another five in mainland Europe (with 3 in Germany). The finals took place in March featuring the best 24 players who had won the most money and played at least 6 events; 3 in Sheffield and 3 in mainland Europe. The prize money at each event was £50,000 or €50,000 at the regular events, with a total of £200,000 available in the Finals. The first event was held in the World Snooker Academy from 25 to 27 June 2010. In the first season the six events at the Academy were sponsored by Star Xing Pai. The prize money for the Finals was increased to £250,000 in 2011/2012. Originally the events played outside Sheffield were called Euro Players Tour Championship, but this distinction was abandoned for the second season.
so they sucked the life out of you
so now what the hell do you do
so your train went off of it's track
back when michael jackson was black
what ya gonna prove
how you gonna prove it
there's no need to waste your life
shatter and abuse it, babe
i'm talking about a time when a dimebag was a dime
no need to dwell upon the here and now, baby
- chorus -
let's pretend it's 1978; we're playing patty cake and baker's men
let's pretend the popsicles we ate all gave us stomach aches on our neighbor's lawn
so you called the chief of police
(this is the pig, this is the pig)
and told him what to do
call the zoo and the justice of peace
and told them what to do
sold your house alone
told your boss to screw it
bought a time machine
grab the wheel and do it, baby
back unto a time when a dimebag was a dime
no need to spend another moment here, baby
* repeat chorus *
hello operator please give me number nine
and if you disconnect me I'll kick your fat
behind the refrigerator there was a piece of glass
miss suzy sat upon it and broke her little
ask me no more questions, i'll tell you no more lies
the boys are in the bathroom zipping up their
flies are in the city and bee stings are our crutch
the boys and girls are necking and asking you just
what ya gonna prove
how you gonna prove it
there's no need to waste your life
shatter and abuse it, babe
i'm talking about a time when a dimebag was a dime
no need to dwell upon the here and now, baby