BTK
BTK may refer to:
Biology
Business
Music
Other
Birth Through Knowledge
Birth Through Knowledge (aka BTK) was a Canadian hip-hop/rock band best known for their 1998 single "Peppyrock," the video for which was nominated for the 1998 MuchMusic Best Video Award. The band consisted of Lo-Ki (vocals), Stone Groove (vocals), DJ Spinz (turntables), Adam Carlo (bass),Sam Cino (drums,percussion) and Matt deMatteo (drums).
After signing onto the Tommyboy/Ignition label, BTK released one album "Birth Thru Knowledge" in 1998.
BTK first came to attention when their song "Corncob Pipe" was included on the sampler disc that Korn released alongside Follow the Leader. They were the first indie band to ever open the main-stage at Edgefest '97. In 1998, the band toured with the Beastie Boys and with Our Lady Peace. They appeared in the 1998 Summersault tour.
The band won the 1997 MuchMusic Best Independent Video Award for "Superchile." They were also nominated for a Juno Award in 1999 in the Best Alternative Album category, losing to Rufus Wainwright.
Footnotes
Bruton's tyrosine kinase
Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development.
Function
BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor.
Btk contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP2, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling.
Clinical significance
Mutations in the BTK gene are implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia). Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified.
Podcasts:
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by Skeptic
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by Skeptic
Scream (peace Of Mind)
by: SkepticI guess
I'm just too selfish
And I guess your "perfect" vision of your child
Has turned out worthless
And I guess since speaking
My own mind is such a rotten crime
And I guess I disappoint my father
And make my mother cry
And your constant negativity
Keeps me far from fine
But I'm done with putting up with you
Just listen one last time
And I'll yell
And I'll scream at the top of my lungs
And I'll try to show you
This is who I've become
(Who I've become)
This house was bitter
The road became sweeter
As the distance grew further
Your words linger louder
An overcast of broken dreams
A sky filled with misery
Where no one but your shadow cares
Is all you claimed was here
These highway lights
Show me
I'm alive
They blur as we move on
To the place where we belong
And I'll yell
And I'll scream at the top of my lungs
And I'll try to show you
This is who I've become
(Who I've become)
Yell and I'll scream at the top of my lungs
And I'll try to show you
This is who I've become
Not become who you thought I would
Leaving all that should be the way you want
Empty hearts and thoughts
Keep in mind that I haven't seen the day
When I knew I was right
(The day)
Will!
Find!
Destiny!
My destiny!
Anxiously waiting to fall asleep
Anxiously waiting to fall asleep
Laying awake, I live my dream
(I found peace)
And I'll yell and I'll scream at the top of my lungs
And I'll try to show you
This is who I've become