Pseudogene

Pseudogenes are functionless relatives of genes that have lost their gene expression in the cell or their ability to code protein. Pseudogenes often result from the accumulation of multiple mutations within a gene whose product is not required for the survival of the organism. Although not protein-coding, the DNA of pseudogenes may be functional, similar to other kinds of non-coding DNA which can have a regulatory role.

Although some pseudogenes do not have introns or a promoter (these pseudogenes are copied from mRNA and incorporated into the chromosome and are called processed pseudogenes), most have some gene-like features such as promoters, CpG islands, and splice sites. They are different from normal genes due to a lack of protein-coding ability resulting from a variety of disabling mutations (e.g. premature stop codons or frameshifts), a lack of transcription, or their inability to encode RNA (such as with rRNA pseudogenes). The term was coined in 1977 by Jacq et al.

Because pseudogenes are generally thought of as the last stop for genomic material that is to be removed from the genome, they are often labeled as junk DNA. We can define a pseudogene operationally as a fragment of nucleotide sequence that resembles a known protein's domains but with stop codons or frameshifts mid-domain. Nonetheless, pseudogenes contain biological and evolutionary histories within their sequences. This is due to a pseudogene's shared ancestry with a functional gene: in the same way that Darwin thought of two species as possibly having a shared common ancestry followed by millions of years of evolutionary divergence (see speciation), a pseudogene and its associated functional gene also share a common ancestor and have diverged as separate genetic entities over millions of years.

Pseudogenes ornaticeps

Pseudogenes ornaticeps is a species of beetle in the family Cerambycidae, and the only species in the genus Pseudogenes. It was described by Fairmaire in 1894.

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