Protection

Protection may refer to:

Film

Music

Places

Safety and technology

Protection (album)

Protection is the second album by Bristol-based trip hop collective Massive Attack. Released in 1994, It was last to feature Tricky as a member of the group, after going solo with his album Maxinquaye in 1995.

Sound

Protection was featured in the top ten of Rolling Stone magazine's 'Coolest Albums of All Time List', calling it "great music for when you're driving around a city at 4 am," due to the 'chill out' nature of the album. Like most of Massive Attack's albums, the music often defies categorisation, ranging from R&B (title track and "Sly") to hip hop/rap ("Karmacoma" and "Eurochild") to reggae-tinged synthpop ("Spying Glass") to classical-influenced electronica instrumentals ("Weather Storm" and "Heat Miser"). The album follows Blue Lines structurally, to the point that the font used on the cover of the album is the same, Helvetica Heavy Italic.

Paul Evans of Rolling Stone gave the album three and a half of five stars calling it "Cool, sexy stuff, it smoothly fuses dub, club and soul, grounding its grace in sampled hip-hop beats."

Protection (Donna Summer song)

"Protection" is a song written by Bruce Springsteen for Donna Summer. It was originally featured on the 1982 Donna Summer album which was produced by Quincy Jones. In 1997 it was also included on One Step Up/Two Steps Back: The Songs Of Bruce Springsteen. It was released as a single in Belgium and Japan and was nominated for a Grammy Award as Best Female Rock Vocal Performance alongside Linda Ronstadt, Pat Benatar, Bonnie Raitt, and Kim Carnes.

David Geffen approached Jon Landau, Springsteen’s manager and producer, and asked if Springsteen would be interested in writing a song for Summer. Summer had just recently signed for Geffen Records. Springsteen agreed to write a song and, while working with Gary U.S. Bonds, he gathered the E Street Band to record a demo. However, when Landau heard the result, "Cover Me", he persuaded Springsteen to keep that song for himself. Springsteen then wrote "Protection". He recorded a version with the E Street Band at The Hit Factory during January or February 1982 and registered it at the United States Copyright Office on March 8, 1982. In the same month Springsteen and Roy Bittan also travelled to Los Angeles to help record Summer’s version of the song. Bruce and Donna allegedly also recorded a duet vocal version at her sessions but it remains unreleased. On the released version by Summer, Springsteen played the guitar solo and can clearly be heard on fadeout vocals. Springsteen’s own version of the song was seriously considered for Born In The USA, however it remains unreleased. He has never performed the song in concert, although it was rehearsed in early 1988 for the upcoming Tunnel Of Love Express Tour.

BTK

BTK may refer to:

Biology

Business

Music

Other

Birth Through Knowledge

Birth Through Knowledge (aka BTK) was a Canadian hip-hop/rock band best known for their 1998 single "Peppyrock," the video for which was nominated for the 1998 MuchMusic Best Video Award. The band consisted of Lo-Ki (vocals), Stone Groove (vocals), DJ Spinz (turntables), Adam Carlo (bass),Sam Cino (drums,percussion) and Matt deMatteo (drums).

After signing onto the Tommyboy/Ignition label, BTK released one album "Birth Thru Knowledge" in 1998.

BTK first came to attention when their song "Corncob Pipe" was included on the sampler disc that Korn released alongside Follow the Leader. They were the first indie band to ever open the main-stage at Edgefest '97. In 1998, the band toured with the Beastie Boys and with Our Lady Peace. They appeared in the 1998 Summersault tour.

The band won the 1997 MuchMusic Best Independent Video Award for "Superchile." They were also nominated for a Juno Award in 1999 in the Best Alternative Album category, losing to Rufus Wainwright.

Footnotes

Bruton's tyrosine kinase

Bruton's tyrosine kinase (abbreviated Btk or BTK) also known as tyrosine-protein kinase BTK is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development.

Function

BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor.

Btk contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 binding induces Btk to phosphorylate phospholipase C, which in turn hydrolyzes PIP₂, a phosphatidylinositol, into two second messengers, inositol triphosphate (IP3) and diacylglycerol (DAG), which then go on to modulate the activity of downstream proteins during B-cell signalling.

Clinical significance

Mutations in the BTK gene are implicated in the primary immunodeficiency disease X-linked agammaglobulinemia (Bruton's agammaglobulinemia). Patients with XLA have normal pre-B cell populations in their bone marrow but these cells fail to mature and enter the circulation. The Btk gene is located on the X chromosome. At least 400 mutations of the BTK gene have been identified.