Protease
A protease (also called a peptidase or proteinase) is any enzyme that performs proteolysis, that is, begins protein catabolism by hydrolysis of the peptide bonds that link amino acids together in a polypeptide chain. Proteases have evolved multiple times, and different classes of protease can perform the same reaction by completely different catalytic mechanisms. Proteases can be found in animals, plants, bacteria, archaea and viruses.
Classifications
Catalytic residue
Proteases can be classified into seven broad groups:
Proteases were first grouped into 84 families according to their evolutionary relationship in 1993, and classified under four catalytic types: serine, cysteine, aspartic, and metallo proteases. The threonine and glutamic-acid proteases were not described until 1995 and 2004 respectively. The mechanism used to cleave a peptide bond involves making an amino acid residue that has the cysteine and threonine (proteases) or a water molecule (aspartic acid, metallo- and glutamic acid proteases) nucleophilic so that it can attack the peptide carboxyl group. One way to make a nucleophile is by a catalytic triad, where a histidine residue is used to activate serine, cysteine, or threonine as a nucleophile. This is not an evolutionary grouping, however, as the nucleophile types have evolved convergently in different superfamilies, and some superfamilies show divergent evolution to multiple different nucleophiles.
Podcasts:
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by Bratz
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by Broadways
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All About You
by: BratzYou've got style looking so sharp
Rocking hot smile you're gonna go far
Believe in yourself
You don't need to be who you're not
All that you need is all that you've got
Just believe in yourself
You should know what you are
Money can't buy
'Cause you should know
It's all about you
It's not about the money you make
It's not about the little mistakes
It's not about the people you know
You'll be fine on your own
It's not about the clothes that you wear
It's not about the car, I swear
It's the little things you say and you do
It's all about you, it's all about you
Have fun in all that you do
Listen to your heart, it's always so true
We believe in you
You can't stop, reach for the stars
Time will tell, tell people who you are
We believe in you
You should know what you are
Money can't buy
You should know
It's all about you
It's not about the money you make
It's not about the little mistakes
It's not about the people you know
You'll be fine on your own
It's not about the clothes that you wear
It's not about the car, I swear
It's the little things you say and you do
It's all about you, it's all about you
If things are spinning around
We'll pick you up when you're down
You don't have to worry my friend
You should know it's all about you
It's not about the people you know
It's not about the seats at the show
It's not about the places you go
It's not about the money you make
It's not about the little mistakes
It's not about the people you know
You'll be fine on your own
It's not about the clothes that you wear
It's not about the car, I swear
It's the little things you say and you do
It's all about you
It's not about the money you make
It's not about the little mistakes
It's not about the people you know
You'll be fine on your own
It's not about the clothes that you wear
It's not about the car, I swear
It's the little things you say and you do
It's all about you
It's not about the money you make
It's not about the little mistakes
It's not about the people you know
You'll be fine on your own
It's not about the clothes that you wear
It's not about the car, I swear
It's the little things you say and you do
Latest News for: protease
Leica Biosystems and Bio-Techne Expand Partnership to Enable Protease-Free Workflows for Automated Spatial Multiomics on ...
Longview News-Journal
02 Apr 2025
Leica Biosystems and Bio-Techne Expand Partnership to Enable Protease-Free Workflows for Automated Spatial Multiomics on the BOND RX Research Staining Instrument
Novonesis launches an unmatched protease portfolio for swift and efficient stain removal (Novozymes A/S)
Targeted degradation of α-Synuclein using an evolved botulinum toxin protease
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